Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder
| Autor: | Carlo Maggini, G Ferraro, Greg Murray, Premananda Indic, Ross J. Baldessarini, Stefano Ghidini, Paola Salvatore |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Cognitive Neuroscience lcsh:Medicine Neuropsychiatric Disorders Motor Activity Biology Behavioral neuroscience Social and Behavioral Sciences Behavioral Neuroscience Young Adult Cognition medicine Psychology Humans Circadian rhythm Bipolar disorder lcsh:Science Psychiatry Behavior Multidisciplinary Mood Disorders Suprachiasmatic nucleus Physics lcsh:R Middle Aged medicine.disease Mental Health Mood Nonlinear Dynamics Mood disorders Interdisciplinary Physics Medicine lcsh:Q Female Abnormality Neuroscience Mathematics Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 6, Iss 5, p e20650 (2011) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0020650 |
| Popis: | Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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