Type 2 diabetes and viral infection; cause and effect of disease

Autor: Felix M. Wensveen, Dario Rahelić, Tamara Turk Wensveen, Dora Gašparini
Jazyk: angličtina
Rok vydání: 2021
Předmět:
endocrine system diseases
Endocrinology
Diabetes and Metabolism
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Immunology
Comorbidity
Review
Disease
Type 2 diabetes
Global Health
antidiabetic drugs
COVID-19
corona virus
diabetes
diabetes mellitus type 2
immune defects
immune system
immunometabolism
infection
insulin resistance
T2D
viral infection
0302 clinical medicine
Diabetes mellitus type 2
Endocrinology
Risk Factors
030212 general & internal medicine
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina
Immune defects
Viral infection
Incidence
Diabetes
General Medicine
3. Good health
Virus Diseases
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Imunologija
Infection
Corona virus
030209 endocrinology & metabolism
Context (language use)
03 medical and health sciences
Immune system
Insulin resistance
Diabetes mellitus
medicine
Internal Medicine
Humans
Endocrine system
Risk factor
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine
Immunometabolism
business.industry
Antidiabetic drugs
nutritional and metabolic diseases
medicine.disease
Diabetes Mellitus
Type 2
Immunology
business
Zdroj: Diabetes Research and Clinical Practice
Volume 172
ISSN: 0168-8227
DOI: 10.1016/j.diabres.2020.108637
Popis: The recent pandemic of COVID-19 has made abundantly clear that Type 2 diabetes (T2D) increases the risk of more frequent and more severe viral infections. At the same time, pro- inflammatory cytokines of an anti-viral Type-I profile promote insulin resistance and form a risk factor for development of T2D. What this illustrates is that there is a reciprocal, detrimental interaction between the immune and endocrine system in the context of T2D. Why these two systems would interact at all long remained unclear. Recent findings indicate that transient changes in systemic metabolism are induced by the immune system as a strategy against viral infection. In people with T2D, this system fails, thereby negatively impacting the antiviral immune response. In addition, immune-mediated changes in systemic metabolism upon infection may aggravate glycemic control in T2D. In this review, we will discuss recent literature that sheds more light on how T2D impairs immune responses to viral infection and how virus-induced activation of the immune system increases risk of development of T2D.
Databáze: OpenAIRE
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