ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical treatment response in dentofacial deformities
| Autor: | Joël Ferri, Constance Delmotte, Gwénaël Raoul, Alain Duhamel, Romain Nicot, James J. Sciote, Alexandre R. Vieira |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Genotype medicine.medical_treatment Population Orthognathic surgery Dentistry Dysfunctional family Polymorphism Single Nucleotide Article 03 medical and health sciences Orthognathic Surgical Procedures 0302 clinical medicine stomatognathic system Risk Factors Radiography Panoramic Humans Medicine Pyrophosphatases Risk factor education education.field_of_study Dentofacial Deformities Phosphoric Diester Hydrolases business.industry Estrogen Receptor alpha 030206 dentistry Temporomandibular Joint Disorders medicine.disease stomatognathic diseases Otorhinolaryngology Cohort Female Surgery Oral Surgery Malocclusion business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Journal of Cranio-Maxillofacial Surgery. 44:1226-1237 |
| ISSN: | 1010-5182 |
| DOI: | 10.1016/j.jcms.2016.07.010 |
| Popis: | Dentofacial deformities are dys-morpho-functional disorders involving the temporomandibular joints (TMJ). Many authors have reported a TMJ improvement in dysfunctional subjects with malocclusion after orthodontic or combined orthodontic and surgical treatment particularly for the relief of pain. In particular, few studies have highlighted the demographic and clinical predictors of response to surgical treatment. To date, no genetic factor has yet been identified as a predictor of response to surgical treatment. The aim of this cohort study is therefore to identify single-nucleotide polymorphisms associated with postoperative temporomandibular disorders (TMD) or with TMJ symptoms after orthognathic surgery. Here, we found the AA genotype of SNP rs1643821 (ESR1 gene) as a risk factor for dysfunctional worsening after orthognathic surgery. In addition, we have identified TT genotype of SNP rs858339 (ENPP1 gene) as a protective factor against TMD in a population of patients with dentofacial deformities. Conversely, the heterozygous genotype AT was identified as a risk factor of TMD with respect to the rest of our population. All these elements are particularly important to bring new screening strategies and tailor future treatment. Perspective This study allows us to identify sub-populations at high risk of developing postoperative temporomandibular disorders after orthognathic surgery procedures. Many other genes of interest could be potential factors influencing the dysfunctional response to orthognathic surgery, particularly genes of the Opera cohort. |
| Databáze: | OpenAIRE |
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