Wound healing, cellular regeneration and plasticity: the elegans way
| Autor: | Sophie Jarriault, Anne Daulny, Laura Vibert |
|---|---|
| Přispěvatelé: | Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I |
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Embryology transdifferentiation [SDV]Life Sciences [q-bio] Cell Plasticity cellular plasticity wound healing Biology innate immune system (axotomy) 03 medical and health sciences medicine Animals Axon Caenorhabditis elegans Process (anatomy) [SDV.BDD]Life Sciences [q-bio]/Development Biology Cell Proliferation [SDV.GEN]Life Sciences [q-bio]/Genetics Regeneration (biology) Transdifferentiation [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis Tissue repair Axons Nerve Regeneration [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics 030104 developmental biology medicine.anatomical_structure [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis Cellular plasticity regeneration Cell Transdifferentiation Wound healing Neuroscience Developmental Biology |
| Zdroj: | International Journal of Developmental Biology International Journal of Developmental Biology, University of the Basque Country Press, 2018, ⟨10.1387/ijdb.180123sj⟩ The International Journal of Developmental Biology |
| ISSN: | 0214-6282 |
| DOI: | 10.1387/ijdb.180123sj |
| Popis: | International audience; Regeneration and wound healing are complex processes that allow organs and tissues to regain their integrity and functionality after injury. Wound healing, a key property of epithelia, involves tissue closure that in some cases leads to scar formation. Regeneration, a process rather limited in mammals, is the capacity to regrow (parts of) an organ or a tissue, after damage or amputation. What are the properties of organs and the features of tissue permitting functional re-growth and repair? What are the cellular and molecular mechanisms underlying these processes? These questions are crucial both in fundamental and applied contexts, with important medical implications. The mechanisms and cells underlying tissue repair have thus been the focus of intense investigation. The last decades have seen rapid progress in the domain and new models emerging. Here, we review the fundamental advances and the perspectives that the use of C. elegans as a model have brought to the mechanisms of wound healing and cellular plasticity, axon regeneration and transdifferentiation in vivo. |
| Databáze: | OpenAIRE |
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