Effects of Oil-treated Mycobacterial Cell Walls on the Organs of Mice
| Autor: | William R. Barclay, W. Brehmer, Edgar Ribi, Robert L. Anacker |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Microbial Physiology and Metabolism
Spleen Biology Tritium Microbiology Cell wall Mice Surface-Active Agents Immune system Cell Wall Immunity Freezing medicine Animals Mineral Oil Macrophage Lung Molecular Biology Aerosols Macrophages Protoplasts Vaccination Mycobacterium tuberculosis medicine.disease Mycobacterium bovis Hydrocarbons Microscopy Electron medicine.anatomical_structure Liver Granuloma Injections Intravenous Immunology BCG Vaccine Emulsions Oils BCG vaccine |
| Zdroj: | Journal of Bacteriology. 94:1736-1745 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.94.5.1736-1745.1967 |
| Popis: | Intravenous vaccination of mice with oil-treated mycobacterial cell walls resulted in a marked macrophage accumulation in the lungs and spleens of vaccinated animals. Injection of oil emulsion alone or of cell walls alone failed to elicit the macrophage response. Although a correlation existed between the magnitude of the macrophage response and the degree of immunity against aerosol challenge with H 37 Rv organisms, the findings presented here do not rule out the possibility that qualitative differences may be present in the macrophages of animals vaccinated against tuberculosis. The ability of oil-treated cell walls to elicit an immune response appeared to be a function of the physical association of cell wall fragments and the surface of oil droplets. |
| Databáze: | OpenAIRE |
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