Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor
| Autor: | Larry P. Feigen, Nancy S. Nicholson, S.G. Panzer-Knodle, Shashidhar N. Rao, Jeffery Alan Zablocki, Masateru Miyano |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Platelet Aggregation
Stereochemistry Molecular Sequence Data Sequence (biology) Platelet Membrane Glycoproteins Fibrinogen chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Peptide synthesis Platelet Carboxylate Amino Acid Sequence Receptors Immunologic Receptor Dipeptide In vitro chemistry Biochemistry Platelet Glycoprotein GPIb-IX Complex Molecular Medicine Oligopeptides Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 35(26) |
| ISSN: | 0022-2623 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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