Increased Thrombogenesity in Patients With Cyanotic Congenital Heart Disease
| Autor: | Hidemi Kajimoto, Kagari Murasaki, Kenjiro Tanoue, Yoshiki Mori, Makoto Nakazawa, Hiroshi Kasanuki, Toshio Nakanishi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty Adolescent Endothelium Thrombomodulin Thrombin Thromboembolism Internal medicine medicine Humans Platelet Platelet activation business.industry Antithrombin Infant General Medicine Hypoxia (medical) Platelet Activation P-Selectin medicine.anatomical_structure Child Preschool Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Protein C medicine.drug |
| Zdroj: | Circulation Journal. 71:948-953 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | Background The basic mechanisms of thromboembolism in cyanotic congenital heart disease (CCHD) have not been well clarified. P-selectin on the platelets reflects platelet activation. Thrombomodulin is a critical cofactor for thrombin-mediated activation of protein C and reflects the anticoagulant activity of the endothelium. The present study was performed to evaluate whether platelet activation exists in patients with CCHD. Methods and results Platelet P-selectin as a marker of platelet activation, plasma thrombomodulin level and protein C activity as markers of anticoagulant activity of the endothelium and thrombin - antithrombin complex III (TAT) were examined in 35 patients with CCHD. Plasma thrombomodulin level (1.1+/-0.9 vs 2.2+/-0.3 FU/ml) and protein C activity (71.1+/-29.8 vs 117.8+/-24.8%) were significantly lower in patients with CCHD as compared with the control subjects. The levels of plasma TAT (255+/-811 vs 1.9+/-0.9 ng/ml) and P-selectin on platelets (6.3 +/-4.5 vs 3.3+/-0.3 mean fluorescence intensity) were significantly higher in the patients with CCHD than in the controls. Four of the CCHD patients who experienced thromboembolic events had elevated levels of platelet P-selectin (p=0.02) compared with CCHD patients without thromboembolic events. Conclusion Platelet activation exists in patients with CCHD and it may play an important role in the thromboembolic events in CCHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|