Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation
| Autor: | Nadia Messaddeq, Daniel Metzger, Arup K. Indra, Adam L. Campbell, Gitali Ganguli-Indra, Olga Golonzhka, Pierre Chambon, Mark Leid, Jean-Marc Bornert, Xiaobo Liang |
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| Přispěvatelé: | Peney, Maité, Department of Biochemistry and Biophysics, Oregon State University (OSU), Department of Pharmaceutical Sciences, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Environmental Health Sciences Center, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Keratinocytes
Time Factors Genotype Cellular differentiation BCL11B Regulator Dermatology Biology Models Biological Biochemistry Permeability Article Mice 03 medical and health sciences 0302 clinical medicine Dermis medicine Animals Cell Lineage Transcription factor Molecular Biology Cell Proliferation 030304 developmental biology Mice Knockout 0303 health sciences Models Genetic Epidermis (botany) integumentary system Tumor Suppressor Proteins Cell Differentiation Cell Biology Cell biology DNA-Binding Proteins Repressor Proteins medicine.anatomical_structure 030220 oncology & carcinogenesis Epidermis Skin morphogenesis Keratinocyte |
| Zdroj: | Journal of Investigative Dermatology Journal of Investigative Dermatology, 2009, 129 (6), pp.1459-70. ⟨10.1038/jid.2008.392⟩ Journal of Investigative Dermatology, Nature Publishing Group, 2009, 129 (6), pp.1459-70. ⟨10.1038/jid.2008.392⟩ |
| ISSN: | 0022-202X 1523-1747 |
| DOI: | 10.1038/jid.2008.392 |
| Popis: | International audience; COUP-TF-interacting protein 2 (CTIP2; also known as Bcl11b) is a transcription factor that plays key roles in the development of the central nervous and immune systems. CTIP2 is also highly expressed in the developing epidermis, and at lower levels in the dermis and in adult skin. Analyses of mice harboring a germline deletion of CTIP2 revealed that the protein plays critical roles in skin during development, particularly in keratinocyte proliferation and late differentiation events, as well as in the development of the epidermal permeability barrier. At the core of all of these actions is a relatively large network of genes, described herein, that is regulated directly or indirectly by CTIP2. The analysis of conditionally null mice, in which expression of CTIP2 was ablated specifically in epidermal keratinocytes, suggests that CTIP2 functions in both cell and non-cell autonomous contexts to exert regulatory influence over multiple phases of skin development, including barrier establishment. Considered together, our results suggest that CTIP2 functions as a top-level regulator of skin morphogenesis. |
| Databáze: | OpenAIRE |
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