Diaphragm muscle sarcopenia into very old age in mice
| Autor: | Heather M. Gransee, Wen Zhi Zhan, Pangdra Vang, Gary C. Sieck, Carlos B. Mantilla, Amrit K. Vasdev |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Force generation Aging Sarcopenia Respiratory complications medicine.medical_specialty Skeletal Muscle Physiology Diaphragm Muscle Fibers Skeletal Ageing and Degeneration 030204 cardiovascular system & hematology lcsh:Physiology Mice 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Diaphragm muscle Critical threshold Pressure medicine Animals Muscle Strength Muscle fibre Original Research Plethysmography Whole Body Respiratory Conditions Disorder and Diseases lcsh:QP1-981 business.industry cross‐sectional area ventilation Respiration Transdiaphragmatic pressure Organ Size medicine.disease Mice Inbred C57BL Muscle Fibers Fast-Twitch Breathing Cardiology Female transdiaphragmatic pressure business 030217 neurology & neurosurgery |
| Zdroj: | Physiological Reports Physiological Reports, Vol 8, Iss 1, Pp n/a-n/a (2020) |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.14305 |
| Popis: | Sarcopenia is the age‐related decline of skeletal muscle mass and function. Diaphragm muscle (DIAm) sarcopenia may contribute to respiratory complications, a common cause of morbidity and mortality in the elderly. From 6 to 24 months (mo) of age, representing ~100% and ~80% survival in C57BL/6 × 129 male and female mice, there is a significant reduction in DIAm force generation (~30%) and cross‐sectional area (CSA) of type IIx and/or IIb muscle fibers (~30%), impacting the ability to perform high force, non‐ventilatory behaviors. To date, there is little information available regarding DIAm sarcopenia in very old age groups. The present study examined DIAm sarcopenia in C57BL/6 × 129 male and female mice at 24, 27, and 30 mo, representing ~80%, ~60%, and ~30% survival, respectively. We hypothesized that survival into older ages will show no further worsening of DIAm sarcopenia and functional impairment in 30 mo mice compared to 24 or 27 mo C57BL/6 × 129 mice. Measurements included resting ventilation, transdiaphragmatic pressure (Pdi) generation across a range of motor behaviors, muscle fiber CSA, and proportion of type‐identified DIAm fibers. Maximum Pdi and resting ventilation did not change into very old age (from 24 to 30 mo). Type IIx and/or IIb fiber CSA and proportions did not change into very old age. The results of the study support a critical threshold for the reduction in DIAm force and Pdi such that survival into very old age is not associated with evidence of progression of DIAm sarcopenia or impairment in ventilation. The purpose of this study was to examine DIAm sarcopenia into very old age in C57BL/6 × 129 male and female mice during a period (24–30 mo) of substantial reduction in survivorship (~80% vs. ~30%, respectively). The results of the study support a critical threshold for the reduction in DIAm force and Pdi such that survival into very old age is not associated with evidence of progression of DIAm sarcopenia or impairment in ventilation. |
| Databáze: | OpenAIRE |
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