Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide in conditions of increased oxygen tension
| Autor: | A. V. Lysenko, N. I. Uskova, E. A. Sametskii, A. M. Mendzheritskii |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Atmosphere Exposure Chambers medicine.medical_treatment Peptide Pharmacology Inhibitory postsynaptic potential Delta Sleep-Inducing Peptide Seizures medicine Animals Wakefulness Cerebral Cortex Hyperoxia chemistry.chemical_classification Hyperbaric Oxygenation Neurotransmitter Agents Chemistry General Neuroscience Electroencephalography Rats Amino acid Oxygen tension Anticonvulsant Anesthesia Excitatory postsynaptic potential Delta sleep-inducing peptide Anticonvulsants medicine.symptom Sleep |
| Zdroj: | Neuroscience and Behavioral Physiology. 27:714-717 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/bf02461934 |
| Popis: | Studies of the protective actions of three doses of delta-sleep-inducing peptide (DSIP) given at different times before barochamber compression of animals to an oxygen tension of 0.7 MPa showed that the optimum DSIP dose is 12 micrograms/100 g. Intraperitoneal administration of this dose of DSIP delayed the onset of generalized convulsive activity by a factor of 2-2.5 in animals exposed to an oxygen tension of 0.7 MPa and promoted normalization of the sleep-walking cycle within 24 h after exposure to hyperbaric oxygen (HBO), by creating an optimal balance between excitatory and inhibitory amino acid neuromediators. |
| Databáze: | OpenAIRE |
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