Sex hormone modulation of serotonin-induced coronary vasodilation in isolated heart

Autor: Antonio M. Cabral, L A Barker, Margareth Ribeiro Moysés
Rok vydání: 2001
Předmět:
Male
coronary circulation
Physiology
Biochemistry
smooth muscle
chemistry.chemical_compound
endothelial function
Testosterone
General Pharmacology
Toxicology and Pharmaceutics
Gonadal Steroid Hormones
lcsh:QH301-705.5
lcsh:R5-920
General Neuroscience
Free Radical Scavengers
General Medicine
Castrated Female
serotonin
Perfusion
Vasodilation
medicine.anatomical_structure
Female
lcsh:Medicine (General)
Serotonin
medicine.medical_specialty
medicine.drug_class
Immunology
Biophysics
Coronary circulation
Coronary Circulation
estradiol
Internal medicine
medicine
Animals
Castration
Rats
Wistar
Dose-Response Relationship
Drug
business.industry
Estrogens
Cell Biology
Rats
Coronary arteries
Endocrinology
lcsh:Biology (General)
chemistry
Estrogen
Coronary perfusion pressure
Vascular Resistance
Coronary vasodilator
business
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 7, Pages: 949-958, Published: JUL 2001
Brazilian Journal of Medical and Biological Research, Vol 34, Iss 7, Pp 949-958 (2001)
Brazilian Journal of Medical and Biological Research v.34 n.7 2001
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
ISSN: 0100-879X
Popis: The present study was designed to evaluate the differences in the coronary vasodilator actions of serotonin (5-HT) in isolated heart obtained from naive or castrated male and female rats that were treated with either estrogen or testosterone. Hearts from 12 groups of rats were used: male and female naive animals, castrated, castrated and treated with 17beta-estradiol (0.5 microg kg(-1) day(-1)) for 7 or 30 days, and castrated and treated with testosterone (0.5 mg kg(-1) day(-1)) for 7 or 30 days. After treatment, the vascular reactivity of the coronary bed was evaluated. Baseline coronary perfusion pressure (CPP) was determined and dose-response curves to 5-HT were generated. Baseline CPP differed between male (70 +/- 6 mmHg, N = 10) and female (115 +/- 6 mmHg, N = 12) naive rats. Maximal 5-HT-induced coronary vasodilation was higher (P
Databáze: OpenAIRE
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