Sex hormone modulation of serotonin-induced coronary vasodilation in isolated heart
Autor: | Antonio M. Cabral, L A Barker, Margareth Ribeiro Moysés |
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Rok vydání: | 2001 |
Předmět: |
Male
coronary circulation Physiology Biochemistry smooth muscle chemistry.chemical_compound endothelial function Testosterone General Pharmacology Toxicology and Pharmaceutics Gonadal Steroid Hormones lcsh:QH301-705.5 lcsh:R5-920 General Neuroscience Free Radical Scavengers General Medicine Castrated Female serotonin Perfusion Vasodilation medicine.anatomical_structure Female lcsh:Medicine (General) Serotonin medicine.medical_specialty medicine.drug_class Immunology Biophysics Coronary circulation Coronary Circulation estradiol Internal medicine medicine Animals Castration Rats Wistar Dose-Response Relationship Drug business.industry Estrogens Cell Biology Rats Coronary arteries Endocrinology lcsh:Biology (General) chemistry Estrogen Coronary perfusion pressure Vascular Resistance Coronary vasodilator business |
Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 7, Pages: 949-958, Published: JUL 2001 Brazilian Journal of Medical and Biological Research, Vol 34, Iss 7, Pp 949-958 (2001) Brazilian Journal of Medical and Biological Research v.34 n.7 2001 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
ISSN: | 0100-879X |
Popis: | The present study was designed to evaluate the differences in the coronary vasodilator actions of serotonin (5-HT) in isolated heart obtained from naive or castrated male and female rats that were treated with either estrogen or testosterone. Hearts from 12 groups of rats were used: male and female naive animals, castrated, castrated and treated with 17beta-estradiol (0.5 microg kg(-1) day(-1)) for 7 or 30 days, and castrated and treated with testosterone (0.5 mg kg(-1) day(-1)) for 7 or 30 days. After treatment, the vascular reactivity of the coronary bed was evaluated. Baseline coronary perfusion pressure (CPP) was determined and dose-response curves to 5-HT were generated. Baseline CPP differed between male (70 +/- 6 mmHg, N = 10) and female (115 +/- 6 mmHg, N = 12) naive rats. Maximal 5-HT-induced coronary vasodilation was higher (P |
Databáze: | OpenAIRE |
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