Correlations between retinal nerve fiber layer thickness and cognitive progression in Parkinson's disease: A longitudinal study
| Autor: | Kai Li, Fen Wang, Chun-Feng Liu, Cheng-Jie Mao, Ya-Li Wang, Jin-Ru Zhang, Jing Chen, Shao-fang Pei, Yu-Lan Cao, Jia-Jing Wu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Retinal Ganglion Cells Longitudinal study medicine.medical_specialty Parkinson's disease genetic structures Nerve fiber layer 03 medical and health sciences Executive Function 0302 clinical medicine Ophthalmology medicine Dementia Humans Cognitive Dysfunction Longitudinal Studies Aged business.industry Montreal Cognitive Assessment Cognition Parkinson Disease Middle Aged medicine.disease Executive functions eye diseases Cognitive test 030104 developmental biology medicine.anatomical_structure Neurology Mental Recall Disease Progression Female sense organs Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Parkinsonismrelated disorders. 82 |
| ISSN: | 1873-5126 |
| Popis: | Background Retinal abnormalities measured by optical coherence tomography (OCT) have been detected in both Parkinson's disease (PD) and Alzheimer's disease (AD). Cognitive impairment is not only found in AD, but 75–90% of PD patients will also develop dementia in the late stage of disease. We assessed whether baseline retinal nerve fiber layer (RNFL) thickness predicted worsening of cognitive status over time and the correlation between RNFL thickness and the detailed impaired cognitive domains in PD. Methods RNFL thickness was measured using high-definition OCT in 78 non-dementia PD patients. Clinical and cognitive assessments were performed at baseline and at 3.61 ± 0.65 years follow-up. Linear mixed-effects models were used to examine associations between RNFL thickness and the changes in cognitive test scores, after adjusting for age, sex, disease duration and education. Results Analysis of outcomes according to baseline RNFL tertiles showed worse performance in global cognitive tests, delayed memory, and executive functions in patients with a thin RNFL. During follow-up, greater cognitive deterioration was found in thin RNFL tertile patients. Lower baseline average RNFL thickness was associated with greater annualized decline in Mini-Mental State Examination and Montreal Cognitive Assessment. Conclusion The correlation between RNFL thickness and cognitive dysfunction suggests that OCT may be useful for predicting cognitive dysfunction in PD patients. |
| Databáze: | OpenAIRE |
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