Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier
| Autor: | Gerald D. Silverberg, Arthur Messier, Miles C. Miller, Doreen P. Osgood, Liliana Gonzalez |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Transcription Genetic Amyloid Receptor expression Receptor for Advanced Glycation End Products Gene Expression Biology Blood–brain barrier Article RAGE (receptor) 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine medicine Animals ATP Binding Cassette Transporter Subfamily B Member 1 RNA Messenger Receptor Messenger RNA Amyloid beta-Peptides General Neuroscience Transporter Rats Inbred F344 Protein Transport 030104 developmental biology medicine.anatomical_structure Endocrinology Blood-Brain Barrier Neurology (clinical) Geriatrics and Gerontology Low Density Lipoprotein Receptor-Related Protein-1 030217 neurology & neurosurgery Homeostasis Developmental Biology |
| Zdroj: | Neurobiology of Aging. 57:178-185 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.05.011 |
| Popis: | Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta (Aβ) peptides and other macromolecules in the brain of the elderly and in the patients with Alzheimer's disease (AD). Aging is the single most important risk factor for AD development. Aβ transport receptor proteins expressed at the blood-brain barrier are significantly altered with age: the efflux transporters lipoprotein receptor-related protein 1 and P-glycoprotein are reduced, whereas the influx transporter receptor for advanced glycation end products is increased. These receptors play an important role in maintaining brain biochemical homeostasis. We now report that, in a rat model of aging, gene transcription is altered in aging, as measured by Aβ receptor gene messenger RNA (mRNA) at 3, 6, 9, 12, 15, 20, 30, and 36 months. Gene mRNA expression from isolated cerebral microvessels was measured by quantitative polymerase chain reaction. Lipoprotein receptor-related protein 1 and P-glycoprotein mRNA were significantly reduced in aging, and receptor for advanced glycation end products was increased, in parallel with the changes seen in receptor protein expression. Transcriptional changes appear to play a role in aging alterations in blood-brain barrier receptor expression and Aβ accumulation. |
| Databáze: | OpenAIRE |
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