NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
| Autor: | Daniel N. Meijles, Patrick J. Pagano, Sanghamitra Sahoo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Ros signalling Biology Bioinformatics medicine.disease_cause Article 03 medical and health sciences Age related Internal medicine Diabetes mellitus medicine Humans Molecular Targeted Therapy chemistry.chemical_classification Reactive oxygen species NADPH oxidase NADPH Oxidases Cardiovascular Agents General Medicine medicine.disease Hedgehog signaling pathway Oxidative Stress 030104 developmental biology Endocrinology chemistry Cardiovascular Diseases biology.protein Oxidation-Reduction Signalling pathways Oxidative stress Signal Transduction |
| Zdroj: | Clinical Science. 130:317-335 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20150087 |
| Popis: | Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source of ROS in the vasculature and are key players in mediating redox signalling under physiological and pathophysiological conditions. In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of ‘longevity genes’ and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. |
| Databáze: | OpenAIRE |
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