Control of synthesis and expression of H-2 heavy chain and beta-2 microglobulin in AKR leukemias
| Autor: | Wilhelm Schmidt, Ulf Henseling, Dorian Bevec, Albert D. R. Alonzo, Hilliard Festenstein |
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| Rok vydání: | 1985 |
| Předmět: |
Transcription
Genetic Immunology Biology Immunoglobulin light chain Cell Line Mice Mice Inbred AKR Antigen Interferon Transcription (biology) Gene expression Genetics medicine Animals RNA Messenger Gene Messenger RNA Leukemia Experimental Beta-2 microglobulin H-2 Antigens Molecular biology Antigens Surface Interferons Immunoglobulin Heavy Chains beta 2-Microglobulin medicine.drug |
| Zdroj: | Immunogenetics. 22:483-494 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/bf00418093 |
| Popis: | In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta-2 microglobulin (beta 2m) light chain, and with the amount of H-2- and beta 2m-specific mRNA present in the tumors. Stimulation of leukemic cells with interferon induced an increased transcription of both H-2 and beta 2m mRNA. These results suggest that there is a mechanism that regulates, at the transcriptional level, the coordinate expression of H-2K and H-2D heavy chains, and the beta 2m light chains encoded by genes on chromosomes 17 and 2, respectively. |
| Databáze: | OpenAIRE |
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