Direct coronary vasodilation induced by intracoronary vasoactive intestinal peptide
| Autor: | Eric J. Eichhorn, S. I. Said, John B. Bedotto, Gregory J. Dehmer, Jeffrey J. Popma, Thomas C. Smitherman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac Catheterization Vasoactive intestinal peptide Hemodynamics Muscle Smooth Vascular Coronary circulation Left coronary artery Oxygen Consumption Internal medicine medicine.artery Coronary Circulation medicine Humans Infusions Intravenous Coronary sinus Aged Pharmacology business.industry Mean Aortic Pressure Heart Middle Aged Coronary Vessels Coronary arteries Vasodilation medicine.anatomical_structure Muscle Tonus Heart catheterization Cardiology Cardiology and Cardiovascular Medicine business Vasoactive Intestinal Peptide |
| Zdroj: | Journal of cardiovascular pharmacology. 16(6) |
| ISSN: | 0160-2446 |
| Popis: | Vasoactive intestinal peptide (VIP) is a neurotransmitter that has been identified in epicardial coronary arteries. To evaluate the direct effect of VIP on coronary hemodynamics and blood flow, graded doses of VIP (0.01, 0.03, 0.10, and 0.30 micrograms/min) were infused into the left coronary artery of 7 patients at the time of diagnostic cardiac catheterization for chest pain syndromes. None of the patients had coronary stenoses greater than 50% during subsequent angiography. Coronary sinus VIP concentrations increased during each infusion (22 +/- 28 pg/ml at baseline to 109 +/- 22 pg/ml at 0.30 micrograms/min; p less than 0.05), but arterial VIP was elevated (39 +/- 29 pg/ml) only at the maximal dose of 0.30 micrograms/min. During all dosages of VIP, heart rate, right atrial and left ventricular end-diastolic pressure, and the heart rate x blood pressure product did not change. Moreover, neither mean aortic pressure nor left ventricular peak + dP/dt changed significantly at doses less than 0.30 micrograms/min; at 0.30 micrograms/min, mean aortic pressure decreased (97 +/- 15 to 90 +/- 15 mm Hg; p less than 0.05) and LV peak + dP/dt increased (1,621 +/- 230 to 1,801 +/- 226 mm Hg/s; p less than 0.05). Compared to baseline, the arterial-coronary sinus O2 content difference and myocardial O2 extraction diminished progressively at the 0.03, 0.10, and 0.30 micrograms/min doses of VIP (118 +/- 12 ml O2/L vs. 94 +/- 15, 70 +/- 9, and 61 +/- 26 ml O2/L, respectively, and 0.64 +/- 0.05 vs. 0.53 +/- 0.10, 0.38 +/- 0.06, and 0.34 +/- 0.15, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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