Persistence of G10P[11] neonatal rotavirus infections in southern India
| Autor: | Binu Ninan, Padma Srikanth, Kulandaipalayam Natarajan Sindhu, Sudhabharathi Reju, Gagandeep Kang, Santhosh Kumar Ganesan, Priya Hemavathy, Sidhartha Giri, Sudhir Babji, Miren Iturriza-Gomara, Sribal Selvarajan, Krithika Gopalakrishnan, Shainey Alokit Khakha, Srinivasan Venugopal, Sasirekha Ramani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Rotavirus
Nursery Pediatrics medicine.medical_specialty Genotype Rotavirus Infections India medicine.disease_cause Asymptomatic Polymerase Chain Reaction Article Persistence (computer science) Neonate Virology Intensive care Medicine Humans music music.instrument business.industry Infant Newborn Rotavirus infection G10P[11] strain Infectious Diseases Lower segment caesarean section medicine.symptom business |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JOURNAL OF CLINICAL VIROLOGY |
| ISSN: | 1873-5967 |
| Popis: | Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and are mostly asymptomatic. Stool samples from neonates admitted for >48 hours in neonatal intensive care units (NICUs) in Vellore (2014-2015) and Chennai (2015-2016) in southern India, and from neonates born at hospitals in Vellore but not admitted to NICUs (2015-2016) were tested for rotavirus by ELISA and genotyped by hemi-nested RT-PCR. Of the 791 neonates, 150 and 336 were recruited from Vellore and Chennai NICUs, and 305 were born in five hospitals in Vellore. The positivity rates in the three settings were 49.3% (74/150), 29.5% (99/336) and 54% (164/305), respectively. G10P[11] was the commonly identified genotype in 87.8% (65/74), 94.9% (94/99) and 98.2% (161/164) of the neonates in Vellore and Chennai NICUs, and those born at Vellore hospitals, respectively. Neonates delivered by lower segment caesarean section (LSCS) at Vellore hospitals, not admitted to NICUs, had a significantly higher odds of acquiring rotavirus infection compared to those delivered vaginally [p=0.002, OR=2.4 (1.4-4.3)]. This report demonstrates the persistence of G10P[11] strain in Vellore and Chennai, indicating widespread neonatal G10P[11] strain in southern India and their persistence over two decades, leading to interesting questions about strain stability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect