Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort
| Autor: | Victor E. Alvarez, Christopher B. Brady, Sean E. Walker, Nazifa Abdul Rauf, Hannah M Burris, Keith R Spencer, Derek Collins, Thor D. Stein, Bertrand R. Huber, Rebecca M. Mathias, Neil W. Kowall, Latease Guilderson, Ann C. McKee, Tarnjit Singh, Ian Robey, James G Averill, Gabriel Walt |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Traumatic brain injury Central nervous system Comorbidity Tissue Banks Pathology and Forensic Medicine Chronic Traumatic Encephalopathy Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine medicine Humans Longitudinal Studies Amyotrophic lateral sclerosis Pathological Veterans Affairs Aged Aged 80 and over business.industry Amyotrophic Lateral Sclerosis Brain General Medicine Original Articles Middle Aged medicine.disease Spinal cord United States Chronic traumatic encephalopathy United States Department of Veterans Affairs 030104 developmental biology medicine.anatomical_structure Neurology Cohort Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neuropathology and experimental neurology. 77(12) |
| ISSN: | 1554-6578 |
| Popis: | Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive head impacts and has been associated with amyotrophic lateral sclerosis (ALS), a fatal, degenerative neuromuscular disorder. The Department of Veterans Affairs Biorepository Brain Bank (VABBB) is a tissue repository that collects antemortem disease progression data and postmortem central nervous system tissue from veterans with ALS. We set out to determine the frequency of co-morbid ALS and CTE in the VABBB cohort and to characterize the clinical, genetic, and pathological distinctions between participants with ALS only and those with both ALS and CTE (ALS+CTE). Of 155 participants, 9 (5.8%) had neuropathologically confirmed ALS+CTE. Participants with ALS+CTE were more likely to have a history of traumatic brain injury (p < 0.001), served during the first Persian Gulf War (p < 0.05), and to have more severe tau pathology within the frontal cortex and spinal cord (p < 0.05). The most common exposures to head impacts included contact sports (n = 5) and military service (n = 2). Clinically, participants with ALS+CTE were more likely to have bulbar onset ALS (p = 0.006), behavioral changes (p = 0.002), and/or mood changes (p < 0.001). Overall, compared with ALS in isolation, comorbid ALS+CTE is associated with a history of TBI and has a distinct clinical and pathological presentation. |
| Databáze: | OpenAIRE |
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