Shunaoxin pills improve the antihypertensive effect of nifedipine and alleviate its renal lipotoxicity in spontaneous hypertension rats
| Autor: | Xuanshuo Liu, Changxiao Liu, Yan Liu, Yu Liu, Shuli Man, Chen Luo, Wenyuan Gao |
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| Rok vydání: | 2020 |
| Předmět: |
Male
China Nifedipine Health Toxicology and Mutagenesis Renal function Blood Pressure 010501 environmental sciences Management Monitoring Policy and Law Pharmacology Toxicology Kidney 01 natural sciences 03 medical and health sciences 0302 clinical medicine Rats Inbred SHR Medicine Animals Antihypertensive Agents 0105 earth and related environmental sciences business.industry Lipid metabolism General Medicine medicine.disease Lipid Metabolism Rats Blood pressure medicine.anatomical_structure Lipotoxicity Adipogenesis 030220 oncology & carcinogenesis Hypertension business Dyslipidemia medicine.drug Drugs Chinese Herbal |
| Zdroj: | Environmental toxicologyREFERENCES. 36(3) |
| ISSN: | 1522-7278 |
| Popis: | Shunaoxin pills (SNX) have been used to treat cerebrovascular diseases in China since 2005. Hypertension is a major risk factor for cerebrovascular disease. This study aimed to explore the synergistic antihypertensive effect of SNX and nifedipine and whether SNX could alleviate nifedipine-induced renal lipotoxicity. During administration, systolic blood pressure was measured weekly. After 5 weeks administration, we examined pathological changes of kidney, renal function, the lipid metabolism index, and adipogenesis genes expression in the kidney tissues, and explored its underlying mechanism. Finally, network pharmacology was used for supplement and verification. As a result, SNX improved the antihypertensive effect of nifedipine and apparently improved nifedipine-induced renal pathological changes, dyslipidemia and the levels of adipogenesis gene expression in kidney tissues. SNX reduced the levels of interleukin-6 and interleukin-1β in renal tissues, down-regulated the production of malondialdehyde, and increased superoxide dismutase activity and the protein expression of heme oxygenase-1 in kidney tissues. Network pharmacology also showed that SNX could improve nifedipine-induced renal lipotoxicity. The combination of SNX and nifedipine had certain benefits in the treatment of hypertension. |
| Databáze: | OpenAIRE |
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