A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape

Autor: Ildiko M. L. Somorjai, Ilya Borisenko, Pedro Martinez, Oshrat Ben-Hamo, Stefano Tiozzo, Denis Khnykin, Eric Röttinger, B. Rinkevich, Alexander V. Ereskovsky, Eugene Berezikov, Lucia Manni, Amalia Rosner, Antonietta Spagnuolo, Bert Hobmayer, Michela Sugni, Loriano Ballarin, O. E. Petukhova, Eve Gazave
Přispěvatelé: Israel Oceanographic and Limnological Research (IOLR), Institució Catalana de Recerca i Estudis Avançats (ICREA), European Research Institute for the Biology of Ageing [Groningen] (ERIBA), University Medical Center Groningen [Groningen] (UMCG), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Fédératif de Recherche - Ressources Marines (IFR MARRES), Université Côte d'Azur (UCA), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Stazione Zoologica Anton Dohrn (SZN), Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Israel Oceanographic and Limnological Research - IOLR (ISRAEL), Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Stem Cell Aging Leukemia and Lymphoma (SALL), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
marine invertebrates
germ cells
Somatic cell
[SDV]Life Sciences [q-bio]
Niche
WHOLE-BODY REGENERATION
Waddington landscape
adult stem cells
General Biochemistry
Genetics and Molecular Biology
VASA-RELATED GENES
03 medical and health sciences
0302 clinical medicine
biology.animal
asexual reproduction CONTENTS
Asymmetric cell division
STARFISH ASTERIAS-RUBENS
RHOPALIAL NERVOUS-SYSTEM
Animals
asexual reproduction
cell lineages
gene expression
niche
regeneration
totipotency
UROCHORDATE BOTRYLLUS-SCHLOSSERI
ComputingMilieux_MISCELLANEOUS
IN-VIVO
030304 developmental biology
0303 health sciences
Amoeboid movement
biology
Regeneration (biology)
Totipotent
Vertebrate
Cell Differentiation
LIFE-CYCLE
Drosophila melanogaster
Phenotype
Evolutionary biology
ENCHYTRAEUS-JAPONENSIS OLIGOCHAETA
INTERSTITIAL CELL
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Adult stem cell
Zdroj: Biological Reviews
Biological Reviews, 2022, 97 (1), pp.299-325. ⟨10.1111/brv.12801⟩
Biological Reviews, Wiley, 2021, ⟨10.1111/brv.12801⟩
Biological Reviews, Wiley, 2021, 97, pp.299-325. ⟨10.1111/brv.12801⟩
Biological Reviews, Wiley, 2021
Biological Reviews, 97(1), 299-325. Wiley
ISSN: 1464-7931
1469-185X
DOI: 10.1111/brv.12801⟩
Popis: Adult stem cells (ASCs) in vertebrates and model invertebrates (e.g. Drosophila melanogaster) are typically long-lived, lineage-restricted, clonogenic and quiescent cells with somatic descendants and tissue/organ-restricted activities. Such ASCs are mostly rare, morphologically undifferentiated, and undergo asymmetric cell division. Characterized by 'stemness' gene expression, they can regulate tissue/organ homeostasis, repair and regeneration. By contrast, analysis of other animal phyla shows that ASCs emerge at different life stages, present both differentiated and undifferentiated phenotypes, and may possess amoeboid movement. Usually pluri/totipotent, they may express germ-cell markers, but often lack germ-line sequestering, and typically do not reside in discrete niches. ASCs may constitute up to 40% of animal cells, and participate in a range of biological phenomena, from whole-body regeneration, dormancy, and agametic asexual reproduction, to indeterminate growth. They are considered legitimate units of selection. Conceptualizing this divergence, we present an alternative stemness metaphor to the Waddington landscape: the 'wobbling Penrose' landscape. Here, totipotent ASCs adopt ascending/descending courses of an 'Escherian stairwell', in a lifelong totipotency pathway. ASCs may also travel along lower stemness echelons to reach fully differentiated states. However, from any starting state, cells can change their stemness status, underscoring their dynamic cellular potencies. Thus, vertebrate ASCs may reflect just one metazoan ASC archetype.
Databáze: OpenAIRE
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