Predictive factors of response to mTOR inhibitors in neuroendocrine tumours
| Autor: | Zatelli, Maria Chiara, Fanciulli, Giuseppe, Malandrino, Pasqualino, NIKE GROUP: Albertelli M, Arvat E, Baldelli R, Berruti A, Bianchi A, Bodei L, Botti G, Corcione F, Daví MV, Delle Fave G, De Marinis L, Di Sarno A, Dicitore A, Fazio N, Ferolla P, Ferone D, Filice A, Gallo M, Giordano C, Giuffrida D, Guarnotta V, Lania A, Lastoria S, Logoluso F, Loli P, Manzoni M, Marchetti M, Martini C, Messina E, Modica R, Motta C, Papotti M, Partelli S, Persico G, Pia A, Piovesan A, Pontecorvi A, Razzore P, Rota F, Scavuzzo F, Sciammarella C, Vitale G., RAMUNDO, VALERIA, FAGGIANO, ANTONGIULIO, COLAO, ANNAMARIA, DE ROSA, GAETANO |
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| Přispěvatelé: | Zatelli, M, Fanciulli, G, Malandrino, P, Ramundo, V, Faggiano, A, Colao, A, Giordano, C, Zatelli, Mc, Nike, Group, Partelli, S, Zatelli, Maria Chiara, Fanciulli, Giuseppe, Malandrino, Pasqualino, Ramundo, Valeria, Faggiano, Antongiulio, Colao, Annamaria, NIKE GROUP: Albertelli, M, Arvat, E, Baldelli, R, Berruti, A, Bianchi, A, Bodei, L, Botti, G, Corcione, F, Daví, Mv, Delle Fave, G, De Marinis, L, DE ROSA, Gaetano, Di Sarno, A, Dicitore, A, Fazio, N, Ferolla, P, Ferone, D, Filice, A, Gallo, M, Giuffrida, D, Guarnotta, V, Lania, A, Lastoria, S, Logoluso, F, Loli, P, Manzoni, M, Marchetti, M, Martini, C, Messina, E, Modica, R, Motta, C, Papotti, M, Persico, G, Pia, A, Piovesan, A, Pontecorvi, A, Razzore, P, Rota, F, Scavuzzo, F, Sciammarella, C, Vitale, G. |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research mTOR inhibitor Endocrinology Diabetes and Metabolism Neuroendocrine tumors Antineoplastic Agent 0302 clinical medicine Endocrinology Neuroendocrine tumours neuroendocrine tumour Treatment resistance MTOR inhibitors Tumor Medical treatment TOR Serine-Threonine Kinases Discovery and development of mTOR inhibitors Response to treatment Patient management Diabetes and Metabolism Neuroendocrine Tumors 030220 oncology & carcinogenesis Neuroendocrine Tumor Human Predictors Animals Antineoplastic Agents Biomarkers Tumor Diagnostic Imaging Humans Protein Kinase Inhibitors medicine.medical_specialty Protein Kinase Inhibitor Early detection predictor Biology NO 03 medical and health sciences mTOR inhibitors neuroendocrine tumours predictors response to treatment Internal medicine medicine mTOR inhibitors neuroendocrine tumours predictors response to treatment mTOR inhibitors neuroendocrine tumours predictors response to treatment Animal medicine.disease 030104 developmental biology Immunology Biomarkers Resource utilization |
| Zdroj: | Endocrine-Related Cancer. 23:R173-R183 |
| ISSN: | 1479-6821 1351-0088 |
| Popis: | Medical treatment of neuroendocrine tumours (NETs) has drawn a lot of attention due to the recent demonstration of efficacy of several drugs on progression-free survival, including somatostatin analogs, small tyrosine kinase inhibitors and mTOR inhibitors (or rapalogs). The latter are approved as therapeutic agents in advanced pancreatic NETs and have been demonstrated to be effective in different types of NETs, with variable efficacy due to the development of resistance to treatment. Early detection of patients that may benefit from rapalogs treatment is of paramount importance in order to select the better treatment and avoid ineffective and expensive treatments. Predictive markers for therapeutic response are under intensive investigation, aiming at a tailored patient management and more appropriate resource utilization. This review summarizes the available data on the tissue, circulating and imaging markers that are potentially predictive of rapalog efficacy in NETs. |
| Databáze: | OpenAIRE |
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