Facile one-pot synthesis of novel dicyanoanilines fused to tetrahydro-4H-thiopyran-4-one ring via Et3N/H2O catalyzed pseudo four-component reaction
| Autor: | Soodabeh Forghani, M. Saeed Abaee, Mohammad M. Mojtahedi, Klaus Harms |
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| Rok vydání: | 2016 |
| Předmět: |
Thiopyran
Aqueous medium Four component 010405 organic chemistry One-pot synthesis General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Isothiochroman chemistry.chemical_compound chemistry Organic chemistry Triethylamine Malononitrile |
| DOI: | 10.6084/m9.figshare.3309520.v1 |
| Popis: | A facile procedure is developed for one-pot synthesis of a new group of dicyanoanilines. Tetrahydro-4H-thiopyran-4-one, 1, undergoes a pseudo four-component reaction with various aldehydes bearing different groups and two equivalents of malononitrile in aqueous media in the presence of triethylamine (Et3N). As a result, novel thiopyran-fused dicyanoanilines 4 are formed efficiently in the reaction mixtures in 90–97% yield within 9–12 h mixing at 40°C. Due to the polarity of the medium, products precipitate in the mixture spontaneously allowing for easy purification by recrystallization avoiding cumbersome chromatographic separations. Characterization of the products was performed by spectroscopic methods and, in one case, was further supported by X-ray crystallographic experiments. |
| Databáze: | OpenAIRE |
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