Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritis
| Autor: | Maarten J. D. van Tol, Ger T. Rijkers, Elisabeth A. M. Sanders, Berent J. Prakken, Arno W. Hoes, Evelien Zonneveld-Huijssoon, Patricia E. Vermeer-De Bondt, Marion A. J. Van Rossum, Carla Engels, Nico M Wulffraat, Wietse Kuis, Fiona R. M. van der Klis, Jan Jaap Van Der Net, Arash Ronaghy |
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| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Blood Bactericidal Activity Adolescent Immunology Arthritis Meningococcal Vaccines Meningococcal disease Rheumatology Recurrence Conjugate vaccine Humans Immunology and Allergy Medicine Pharmacology (medical) Child Netherlands biology business.industry Tetanus Antibody titer Infant medicine.disease Arthritis Juvenile Meningococcal Infections Vaccination Child Preschool Immune System Immunoglobulin G biology.protein Female Antibody business Immunosuppressive Agents Juvenile rheumatoid arthritis |
| Zdroj: | Arthritis and rheumatism, 56(2), 639-646. John Wiley and Sons Inc. |
| ISSN: | 0004-3591 |
| DOI: | 10.1002/art.22399 |
| Popis: | Objective To determine whether vaccinations aggravate the course of autoimmune diseases such as juvenile idiopathic arthritis (JIA) and whether the immune response to vaccinations may be hampered by immunosuppressive therapy for the underlying disease. Methods In this multicenter cohort study, 234 patients with JIA (ages 1–19 years) were vaccinated with meningococcal serogroup C (MenC) conjugate to protect against serogroup C disease (caused by Neisseria meningitidis). Patients were followed up for disease activity for 1 year, from 6 months before until 6 months after vaccination. IgG antibody titers against MenC polysaccharide and the tetanus carrier protein were determined by enzyme-linked immunosorbent assay and toxin binding inhibition assay, respectively. A serum bactericidal assay was performed to determine the function of the anti-MenC antibodies. Results No change in values for any of the 6 components of the core set criteria for juvenile arthritis disease activity was seen after MenC vaccination. Moreover, no increase in the frequency of disease relapse was detected. Mean anti-MenC IgG concentrations in JIA patients rose significantly within 6–12 weeks after vaccination. Of 157 patients tested, 153 were able to mount anti-MenC IgG serum levels >2 μg/ml, including patients receiving highly immunosuppressive medication. The 4 patients with a lower anti-MenC antibody response displayed sufficient bactericidal activity despite receiving highly immunosuppressive medication. Conclusion The MenC conjugate vaccine does not aggravate JIA disease activity or increase relapse frequency and results in adequate antibody levels, even in patients receiving highly immunosuppressive medication. Therefore, patients with JIA can be vaccinated safely and effectively with the MenC conjugate. |
| Databáze: | OpenAIRE |
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