Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone

Autor:	Cas LeMaster, Eric S Geanes, Elizabeth R Fraley, Rangaraj Selvarangan, Todd Bradley
Rok vydání:	2022
Předmět:	COVID-19 Vaccines Infectious Diseases SARS-CoV-2 Vaccination Antibody Affinity Humans COVID-19 Immunology and Allergy Viral Vaccines Antibodies Viral Antibodies Neutralizing
Zdroj:	The Journal of Infectious Diseases. 226:1712-1716
ISSN:	1537-6613 0022-1899
DOI:	10.1093/infdis/jiac247
Popis:	The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after 2 doses of the Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher antibody levels and avidity to the Omicron variant compared to individuals vaccinated without infection. This suggested that COVID-19 infection before vaccination elicited a higher magnitude and affinity antibody response to the Omicron variant, and repeated exposure through infection or vaccine may be required to improve immunity to emerging SARS-CoV-2 variants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65f1394ef2ff8e1edebd10eb5d70181 https://doi.org/10.1093/infdis/jiac247 Zobrazit plný text záznamu