Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility
| Autor: | Tiina Murto, Agneta Yngve, Anneli Stavreus-Evers, Andres Salumets, Signe Altmäe, Torbjörn K. Nilsson, A. Skoog Svanberg, Kjell Wånggren |
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| Rok vydání: | 2013 |
| Předmět: |
Infertility
Adult medicine.medical_specialty Folic acid blood Homocysteine Reproduktionsmedicin och gynekologi Fertilization in Vitro folate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Folic Acid Pregnancy Obstetrics Gynecology and Reproductive Medicine parasitic diseases medicine IVF pregnancy Humans 030212 general & internal medicine Unexplained infertility Gynecology 030219 obstetrics & reproductive medicine business.industry Obstetrics Pregnancy Outcome Livsmedelsvetenskap food and beverages Obstetrics and Gynecology medicine.disease Folic acid supplementation 3. Good health Reproductive Medicine chemistry Folic acid dietary supplement Dietary Supplements Female infertility business Infertility Female Food Science Developmental Biology |
| Zdroj: | Reproductive BioMedicine |
| ISSN: | 1472-6491 |
| Popis: | Folic acid supplements are commonly used by infertile women and lead to a positive folate status. However, the effect of folic acid supplements on pregnancy outcome in women with unexplained infertility has not been well investigated. This study evaluated folic acid supplement use and folate status in women with unexplained infertility in relation to pregnancy outcome. In addition, use of folic acid supplements and folate status were compared between women with unexplained infertility and fertile, nonpregnant control women. Women with unexplained infertility used significantly more folic acid supplements and had higher median total folic acid intake from supplements compared with fertile control women (both P < 0.001). Women with unexplained infertility also had significantly higher median plasma folate and lower median plasma homocysteine concentrations than fertile women (both P < 0.001), but folic acid supplementation or folate status were not related to pregnancy outcome in women with unexplained infertility. In conclusion, folic acid supplementation or good folate status did not have a positive effect on pregnancy outcome following infertility treatment in women with unexplained infertility. Funding Agencies:Family Planning FoundationFödelsefonden, Uppsala, SwedenRegional Research Foundation, Örebro, SwedenPampers Scholarship, SwedenPraktikertjänst, Stockholm, SwedenMarie Curie postdoctoral fellowship 329812 |
| Databáze: | OpenAIRE |
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