Spontaneous and Induced Animal Models for Cancer Research
| Autor: | Radu Pirlog, Ioana Berindan-Neagoe, Schuyler S. Korban, Atanas G. Atanasov, Richard Ionut Feder, Raluca Munteanu, Anca Onaciu, Vlad Cristian Munteanu, Diana Gulei, Alexandru Irimie, Lajos Raduly |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
models of disease Clinical Biochemistry Review Biology 03 medical and health sciences 0302 clinical medicine avatar mice medicine cancer CRISPR Genetic variability preclinical studies lcsh:R5-920 therapy Cas9 Laboratory mouse Cancer genetically modified medicine.disease Genetically modified organism Human tumor 030104 developmental biology biomedical research 030220 oncology & carcinogenesis Cancer research Adaptation lcsh:Medicine (General) |
| Zdroj: | Diagnostics Diagnostics, Vol 10, Iss 660, p 660 (2020) |
| ISSN: | 2075-4418 |
| Popis: | Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented. |
| Databáze: | OpenAIRE |
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