The increase in medial prefrontal glutamate/glutamine concentration during memory encoding is associated with better memory performance and stronger functional connectivity in the human medial prefrontal-thalamus-hippocampus network

Autor: Jens Wiltfang, Indira Tendolkar, Donghyun Hong, Jan Willem Thielen, David G. Norris, Guillén Fernández, Seyedmorteza Rohani Rankouhi
Přispěvatelé: Magnetic Detection and Imaging
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Magnetic Resonance Spectroscopy
hippocampus
Glutamine
Medizin
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
UT-Hybrid-D
Hippocampus
memory
GABA
0302 clinical medicine
Thalamus
130 000 Cognitive Neurology & Memory
Image Processing
Computer-Assisted
Names
Prefrontal cortex
Correlation of Data
Episodic memory
Research Articles
Brain Mapping
Neocortex
Radiological and Ultrasound Technology
fMRI
MR spectroscopy
Glutamate receptor
Psychophysiological Interaction
Magnetic Resonance Imaging
medial prefrontal
medicine.anatomical_structure
Neurology
Female
Anatomy
Psychology
Research Article
Adult
Biophysics
Glutamic Acid
Prefrontal Cortex
glutamate
150 000 MR Techniques in Brain Function
03 medical and health sciences
Young Adult
medicine
Humans
Radiology
Nuclear Medicine and imaging
Association (psychology)
functional connectivity
Association Learning
030104 developmental biology
nervous system
Face
network
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Photic Stimulation
Zdroj: Human Brain Mapping
Human Brain Mapping, 39, 6, pp. 2381-2390
Human brain mapping, 39(6), 2381-2390. Wiley-Liss Inc.
Human Brain Mapping, 39, 2381-2390
ISSN: 1097-0193
1065-9471
Popis: Contains fulltext : 193482.pdf (Publisher’s version ) (Open Access) The classical model of the declarative memory system describes the hippocampus and its interactions with representational brain areas in posterior neocortex as being essential for the formation of long-term episodic memories. However, new evidence suggests an extension of this classical model by assigning the medial prefrontal cortex (mPFC) a specific, yet not fully defined role in episodic memory. In this study, we utilized 1H magnetic resonance spectroscopy (MRS) and psychophysiological interaction (PPI) analysis to lend further support for the idea of a mnemonic role of the mPFC in humans. By using MRS, we measured mPFC gamma-aminobutyric acid (GABA) and glutamate/glutamine (GLx) concentrations before and after volunteers memorized face-name association. We demonstrate that mPFC GLx but not GABA levels increased during the memory task, which appeared to be related to memory performance. Regarding functional connectivity, we used the subsequent memory paradigm and found that the GLx increase was associated with stronger mPFC connectivity to thalamus and hippocampus for associations subsequently recognized with high confidence as opposed to subsequently recognized with low confidence/forgotten. Taken together, we provide new evidence for an mPFC involvement in episodic memory by showing a memory-related increase in mPFC excitatory neurotransmitter levels that was associated with better memory and stronger memory-related functional connectivity in a medial prefrontal-thalamus-hippocampus network. 10 p.
Databáze: OpenAIRE
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