Early Vocal Development in Tuberous Sclerosis Complex
| Autor: | D. Kimbrough Oller, Ellen E. Ellison, Edina R. Bene, Gordon Ramsay, Tanjala T. Gipson, Helen L. Long |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Language Disorders Future studies Autism Spectrum Disorder Environment analysis Infant Audiology Poor language medicine.disease Babbling Article Tuberous sclerosis Child Development Developmental Neuroscience Neurology Speech development Autism spectrum disorder Tuberous Sclerosis Pediatrics Perinatology and Child Health medicine Autism Humans Neurology (clinical) Psychology |
| Zdroj: | Pediatr Neurol |
| Popis: | Background Our goal was to assess for the first time early vocalizations as precursors to speech in audio-video recordings of infants with tuberous sclerosis complex (TSC). Methods We randomly selected 40 infants with TSC from the TSC Autism Center of Excellence Research Network dataset. Using human observers, we analyzed 74 audio-video recordings within a flexible software-based coding environment. During the recordings, infants were engaged in developmental testing. We determined syllables per minute (volubility), the number of consonant-vowel combinations, such as ‘ba’ (canonical babbling), and the canonical babbling ratio (canonical syllables/total syllables) and compared the data with two groups of typically developing (TD) infants. One comparison group's data had come from a laboratory setting, while the other's had come from all-day Language Environment Analysis recordings at home. Results Compared with TD infants in laboratory and all-day Language Environment Analysis recordings, entry into the canonical babbling stage was delayed in the majority of infants with TSC, and the canonical babbling ratio was low (TD mean = 0.346, SE = 0.19; TSC mean = 0.117, SE = 0.023). Volubility level in infants with TSC was less than half that of TD infants (TD mean = 9.82, SE = 5.78; TSC mean = 3.99, SE = 2.16). Conclusions Entry into the canonical stage and other precursors of speech development were delayed in infants with TSC and may signal poor language and developmental outcomes. Future studies are planned to assess prediction of language and developmental outcomes using these measures in a larger sample and in more precisely comparable recording circumstances. |
| Databáze: | OpenAIRE |
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