Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats
| Autor: | Pamela S. Hunt |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_treatment Physiology Alcohol Article Choline Behavioral Neuroscience chemistry.chemical_compound medicine Animals Fear conditioning Freezing Reaction Cataleptic Adverse effect Saline Nootropic Agents Analysis of Variance Ethanol Learning Disabilities Body Weight Central Nervous System Depressants Fear Rats Disease Models Animal Animals Newborn chemistry Conditioning Operant Conditioning Female Psychology Neuroscience Choline chloride |
| Zdroj: | Behavioral Neuroscience. 126:593-598 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/a0028878 |
| Popis: | Supplemental choline during early stages of development can result in long-lasting improvements to memory function. In addition, pre- or postnatal choline has been shown to be protective against some of the adverse effects of early alcohol exposure. The present experiment examined whether supplemental choline given to rats would protect against the effects of posttraining alcohol administration on trace fear conditioning. Posttraining alcohol exposure in adolescent rats results in poor performance in this hippocampus-dependent task, although delay conditioning is unaffected. Here, rats were given an s.c. injection of either saline or choline chloride daily on postnatal days (PD) 15-26. On PD 30 subjects were trained in a trace fear conditioning procedure. For the next 3 days animals were administered 2.5 g/kg ethanol or water control, and conditional stimulus (CS)-elicited freezing was measured on PD 34. Results indicated that posttraining alcohol disrupted the expression of trace conditioning and that supplemental choline on PD 15-26 was protective against this effect. That is, choline-treated animals subsequently given posttraining ethanol performed as well as animals not given ethanol. These results indicate that supplemental choline given during the periweaning period protects against ethanol-induced impairments in a hippocampus-dependent learning task. Findings contribute to the growing literature showing improvements in learning and memory in subjects given extra dietary choline during critical periods of brain development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|