Protection of Human Myocardium In Vitro by KATP Activation with Low Concentrations of Bimakalim
| Autor: | Paolo Emilio Puddu, E. Tonelli, Francesco Monti, Sandra Picard, Giovanni Ruvolo, Anna Criniti, F. Del Monte, Pierre Ducouret, René Rouet, K. Iwashiro, Ugo Papalia |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Inotrope Dihydropyridines medicine.medical_specialty Potassium Channels Time Factors In Vitro Techniques Glibenclamide Contractility Adenosine Triphosphate Dobutamine Isometric Contraction Internal medicine Glyburide medicine Humans Benzopyrans Drug Interactions Heart Atria Hypoxia Pharmacology Dose-Response Relationship Drug business.industry Myocardium Hypoxia (medical) Myocardial Contraction Oxygen Endocrinology Mechanism of action Inotropism Circulatory system medicine.symptom Cardiology and Cardiovascular Medicine business Muscle Contraction medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 34:162-172 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199907000-00025 |
| Popis: | We investigated whether the adenosine triphosphate (ATP)-sensitive K + (K ATP ) channel activation by bimakalim, at concentrations devoid of both negative inotropic and action-potential duration (APD) shortening effects, might exhibit myocardial protection after hypoxia and reoxygenation in human atrial myocardium by using 112 preparations. The recovery of contractility of human atrial trabeculae, subjected either to short-duration (5 min) or to long-duration (60 min) and severe (high pacing rate) hypoxia followed by reoxygenation, was assessed by challenging with dobutamine. Treated preparations were exposed to 10 or 100 nM bimakalim, I μM glibenclamide, or both before hypoxia. Variations of isometric developed tension (%DT) or APD 90 were studied. At concentrations |
| Databáze: | OpenAIRE |
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