Increased plasma fibrinogen predicts one-year mortality in patients with acute ischemic stroke
| Autor: | Wojciech Turaj, Jacek Strojny, Mateusz G. Adamski, Roman Pułyk, Tomasz Dziedzic, Andrzej Szczudlik, Agnieszka Slowik |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Hyperfibrinogenemia Fibrinogen Leukocyte Count Sex Factors Predictive Value of Tests White blood cell Internal medicine Humans Medicine Risk factor Stroke Aged business.industry Vascular disease Cerebral infarction Age Factors Middle Aged medicine.disease Survival Analysis Surgery medicine.anatomical_structure Neurology Predictive value of tests Acute Disease Multivariate Analysis Cardiology Female Neurology (clinical) business Biomarkers Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 246:13-19 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2006.01.020 |
| Popis: | Background and purpose: Increased plasma fibrinogen is a risk factor for vascular diseases related to atherosclerosis. Its long-term predictive value in stroke survivors is not established. We conducted this study to establish the significance of hyperfibrinogenemia as the possible predictor of 30-day and one-year mortality in patients with acute ischemic stroke. Methods: We studied 900 unselected patients with ischemic stroke admitted to the hospital within 24 h after onset of symptoms. We noted demographic data, risk factors for stroke, neurological deficit and disturbances of consciousness on admission. We measured plasma concentration of fibrinogen and the body temperature on day 1 and registered vital status at 1, 3, 6 and 12 months after stroke. Results: Mean concentration of plasma fibrinogen was 2.9 g/L and 25.2% of patients had increased plasma concentration of fibrinogen (i.e. 3.5 g/L) on day 1. Patients with hyperfibrinogenemia were more likely to die after 1, 3, 6 and 12 months than those with normal plasma fibrinogen (21.1% vs. 15.6%, 36.4% vs. 24.6%, 42.6% vs. 27.3%, 45.7% vs. 31.2%, respectively; P |
| Databáze: | OpenAIRE |
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