The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis
| Autor: | Kenan Özler |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty WOMAC Disintegrins Vesicular Transport Proteins Osteoarthritis 030204 cardiovascular system & hematology Logistic regression Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Synovial Fluid Serglycin Medicine Synovial fluid Humans 030212 general & internal medicine Prospective Studies Thrombospondin Metalloproteinase business.industry General Medicine Osteoarthritis Knee medicine.disease ADAMTS4 Case-Control Studies Metalloproteases Female Proteoglycans business Thrombospondins |
| Zdroj: | Irish journal of medical science. 188(3) |
| ISSN: | 1863-4362 |
| Popis: | The first research to determine synovial fluid ADAMTS4 and serglycin levels in osteoarthritis and OA progression. We aimed to determine ADAMTS4 and serglycin levels, interactions, and changes in the synovial fluid of knee OA, and also to determine effective in OA progression. A case-control study was carried out including a total of 88 participants (29 patients late OA [LOA], 28 early OA [EOA], and 30 controls). Synovial fluid serglycin and ADAMTS4 levels were measured by commercially available ELISA kits, and knee functions of the patients were evaluated with The Western Ontario and McMaster Universities Osteoarthritis score (WOMAC). Logistic regression analysis was applied for the associated with progression of OA. Synovial fluid ADAMTS4 and serglycin levels were significantly higher in LOA than EOA and control groups (p |
| Databáze: | OpenAIRE |
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