The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review
| Autor: | Agustin Rascon Chu, Elizabeth Carvajal-Millan, Alma C. Campa-Mada, Maria Dolores Figueroa-Pizano, Karla G. Martínez-Robinson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
chronic inflammation Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Health Informatics Inflammation Review Diabetes mellitus Internal medicine medicine Significant risk business.industry impaired immune system ACE2 polymorphisms Mortality rate Incidence (epidemiology) Public Health Environmental and Occupational Health COVID-19 medicine.disease Acquired immune system diabetes mellitus diabetogenic effect medicine.symptom Public aspects of medicine RA1-1270 business SARS-CoV-2 receptor |
| Zdroj: | AIMS Public Health AIMS Public Health, Vol 8, Iss 4, Pp 720-742 (2021) |
| ISSN: | 2327-8994 |
| Popis: | Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have increased mortality rates. Here, we review the possible underlying mechanisms involved in DM that led to worse outcomes in COVID-19. The impacts of hyperglycemia side effects, secondary comorbidities, weakened innate and adaptive immunity, chronic inflammation, and poor nutritional status, commonly present in DM, are discussed. The role of the SARS-CoV-2 receptor and its polymorphic variations on higher binding affinity to facilitate viral uptake in people with DM were also considered. Clinical differences between individuals with type 1 DM and type 2 DM affected by COVID-19 and the potential diabetogenic effect of SARS-CoV-2 infection were addressed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|