Very long-term sequelae of craniopharyngioma
| Autor: | Sebastian J C M M Neggers, Alof H G Dallenga, Marie-Lise C. van Veelen-Vincent, Marry M. van den Heuvel-Eibrink, Aart-Jan van der Lely, Erna M.C. Michiels, J Herbert van den Berge, Coriene E. Catsman-Berrevoets, Carolien M. van Rij, Mark Wijnen, Joseph A M J L Janssen |
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| Přispěvatelé: | Internal Medicine, Pediatrics, Neurology, Neurosurgery, Radiotherapy |
| Rok vydání: | 2017 |
| Předmět: |
Male
Risk Aging medicine.medical_specialty Pediatrics Endocrinology Diabetes and Metabolism medicine.medical_treatment Vision Disorders 030209 endocrinology & metabolism Hypopituitarism Growth hormone deficiency Cohort Studies Craniopharyngioma 03 medical and health sciences 0302 clinical medicine Endocrinology Interquartile range Internal medicine Prevalence medicine Humans Pituitary Neoplasms Obesity Age of Onset Child Survival analysis Netherlands Retrospective Studies business.industry Retrospective cohort study General Medicine medicine.disease Combined Modality Therapy Survival Analysis Radiation therapy Cross-Sectional Studies Child Preschool Female Neoplasm Recurrence Local Age of onset business 030217 neurology & neurosurgery Follow-Up Studies Cohort study |
| Zdroj: | European Journal of Endocrinology, 176(6), 755-767. Bioscientifica Ltd |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | Objective Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Design Cross-sectional study based on retrospective data. Methods We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5–23 years). Initial craniopharyngioma treatment approaches included gross total resection (n = 25), subtotal resection without radiotherapy (n = 44), subtotal resection with radiotherapy (n = 25), cyst aspiration without radiotherapy (n = 8), and 90Yttrium brachytherapy (n = 21). Results Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma. Conclusions Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease. |
| Databáze: | OpenAIRE |
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