Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder
| Autor: | Patrick Bach, Christina Dinter, Damian Karl, Karl Mann, Anne Koopmann, Falk Kiefer, Derik Hermann, Sabine Vollstädt-Klein, J. Malte Bumb |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Narcotic Antagonists Alcohol Craving Striatum Alcohol use disorder chemistry.chemical_compound 0302 clinical medicine Prospective Studies Controlled drinking Original Investigation Harm reduction Cross-Over Studies Middle Aged Magnetic Resonance Imaging Naltrexone Opioid receptors Alcoholism medicine.anatomical_structure Female medicine.symptom Cues medicine.drug Adult medicine.medical_specialty Placebo Alcohol cue-reactivity 03 medical and health sciences Reward system Young Adult Double-Blind Method Internal medicine medicine Humans Nalmefene Pharmacology business.industry Ventral striatum medicine.disease Reduced drinking Pharmacotherapy 030227 psychiatry Endocrinology chemistry Ventral Striatum business 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Psychopharmacology |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Rationale Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response to nalmefene are available. Objectives We tested the effect of a single dose of 18 mg nalmefene on neuronal cue-reactivity in the ventral and dorsal striatum and subjective craving. Methods Eighteen non-treatment-seeking participants with alcohol use disorder (67% male, M = 50.3 ± 13.9 years) with a current high-risk drinking level (M = 76.9 ± 52 g of pure alcohol per day) were investigated using a cue-reactivity task during functional magnetic resonance imaging (fMRI) in a double-blind, placebo-controlled, cross-over study/design. In addition, self-reported craving was assessed before and after exposure to alcohol cues. Results An a priori defined region of interest (ROI) analysis of fMRI data from 15 participants revealed that nalmefene reduced alcohol cue-reactivity in the ventral, but not the dorsal striatum. Additionally, the subjective craving was significantly reduced after the cue-reactivity task under nalmefene compared to placebo. Conclusion In the present study, reduced craving and cue-reactivity to alcohol stimuli in the ventral striatum by nalmefene indicates a potential anti-craving effect of this drug via attenuation of neural alcohol cue-reactivity. |
| Databáze: | OpenAIRE |
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