| Autor: |
Bachar, El Oumeiri, Philippe, van de Borne, Géraldine, Hubesch, Pascale, Jespers, Laurence, Dewachter, Constantin, Stefanidis, Kathleen, Mc Entee, Frédéric, Vanden Eynden |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Basic and Clinical Physiology and Pharmacology. 33:743-750 |
| ISSN: |
2191-0286 |
| DOI: |
10.1515/jbcpp-2022-0215 |
| Popis: |
Objectives Both N-terminal fragment of B-type natriuretic peptide (NT-proBNP) and soluble isoform of ST2 (sST2) have been identified as biomarkers of heart failure. We evaluated the plasma levels of NT-proBNP and sST2 in a rat model of severe aortic valve regurgitation (AR) and correlated these findings with echocardiographic measurements. We also examined the impact of omecamtiv mecarbil (OM) on these parameters. Methods The plasma levels of NT-proBNP and sST2 were measured in 18 rats both before and 2 months after surgical induction of AR, and at these same time points, in six rats assigned to a sham-procedure control group. Plasma biomarkers were then measured again after infusion of OM or placebo in rats with AR (n=8 and 10, respectively) and OM alone in the sham control rats (n=6). Echocardiographic measurements were collected before and 2 months after induction of AR. Results Our results revealed increased levels of plasma NT-proBNP (219 ± 34 pg/mL vs. 429 ± 374 pg/mL; p Conclusions Because sST2 increased markedly, whereas NT-proBNP remained unchanged, when OM was administered, we hypothesize that sST2 has a distinct capability to detect deleterious effects of passive muscle tension, not reliably assessed by NT-proBNP, in the setting of AR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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