Trends in all-cause five-year mortality after head and neck cancers diagnosed over a period of 33 years. Focus on estimated degree of association with human papillomavirus
| Autor: | Susanne K. Kjaer, Christian Munk, Kirsten Frederiksen, Thor Schütt Svane Nielsen, Malene F. Svahn, Christian von Buchwald |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Denmark Alphapapillomavirus 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Carcinoma medicine Humans Radiology Nuclear Medicine and imaging Degree of association Registries Human papillomavirus Stage (cooking) Head and neck Aged Neoplasm Staging Squamous Cell Carcinoma of Head and Neck Proportional hazards model business.industry Papillomavirus Infections Head and neck cancer Age Factors Hematology General Medicine Middle Aged Prognosis medicine.disease Surgery stomatognathic diseases 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female business Cohort study |
| Zdroj: | Acta Oncologica. 55:1084-1090 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/0284186x.2016.1185148 |
| Popis: | Factors influencing survival after head and neck cancer (HNC) include among others stage, age, and sex. More recently, human papillomavirus (HPV) positivity has been described as a favorable prognostic factor in relation to some HNCs.In this nationwide register-based cohort study of all 20 925 individuals diagnosed with squamous cell carcinoma of the head and neck (HNSCC) in Denmark 1978-2010, we investigate secular trends in all-cause five-year mortality after HNSCC according to the anticipated degree of association with HPV using a Cox proportional hazards model. Furthermore, we examine whether any trend over time differed according to sex, stage, and age at diagnosis.All-cause five-year mortality after HNSCC has decreased over time. The greatest decrease was seen in the last decade (2000-2010) among patients with HNSCC at sites estimated to be strongly associated with HPV, i.e. the base of the tongue and the tonsils, where a 28% decrease per five years (e.g. HRAll-cause five-year mortality after HNSCC has decreased significantly in Denmark from 1978 to 2010, especially for HNSCCs at sites anticipated to be strongly associated with HPV, possibly due to an increasing proportion of HPV-positive HNSCCs. |
| Databáze: | OpenAIRE |
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