Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets
Autor: | Władysław P. Węglarz, Piotr Kulinowski, Ewelina Juszczyk, Ewelina Baran, Przemysław Dorożyński, Josep M. Suñé-Negre, Artur Birczyński, Dorota Majda, Pilar Pérez-Lozano, Encarna García-Montoya |
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Rok vydání: | 2021 |
Předmět: |
magnetic resonance imaging (MRI)
differential scanning calorimetry (DSC) Analytical chemistry 02 engineering and technology 030226 pharmacology & pharmacy lcsh:Technology Article sodium alginate Síntesi de fàrmacs 03 medical and health sciences Matrix (mathematics) Drug synthesis 0302 clinical medicine multi-echo spin-echo (MSME) T2 relaxation time mapping General Materials Science lcsh:Microscopy Water content Sodium alginate lcsh:QC120-168.85 hydrophilic polymeric matrices chemistry.chemical_classification Water transport lcsh:QH201-278.5 Nanopartícules compressed matrix tablets lcsh:T Spatiotemporal Analysis Nondestructive analysis mass transport spatial water distribution Polymer 021001 nanoscience & nanotechnology ultrashort echo time (UTE) Infiltration (hydrology) chemistry lcsh:TA1-2040 Nanoparticles lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering water–polymer interaction 0210 nano-technology lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
Zdroj: | Materials Dipòsit Digital de la UB Universidad de Barcelona Materials, Vol 14, Iss 646, p 646 (2021) Volume 14 Issue 3 |
ISSN: | 1996-1944 |
Popis: | Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. In the regions of high water content, where sampling was infeasible due to gel/sol consistency, magnetic resonance imaging (MRI) enabled characterization with an order of magnitude higher spatial resolution. The minimally hydrated layer (MHL), infiltration layer (IL) and fully hydrated layer (FHL) were identified in the unilaterally hydrated matrices. The MHL gained water from the first hour of incubation (5–10% w/w) and at 4 h total water content was 29–39% with nonfreezing pool of 28–29%. The water content in the IL was 45–47% and at 4 h it reached ~50% with the nonfreezing pool of 28% and T2 relaxation time < 10 ms. The FHL consisted of gel and sol layer with water content of 85–86% with a nonfreezing pool of 11% at 4 h and T2 in the range 20–200 ms. Hybrid destructive/nondestructive analysis of alginate matrices under hydration was proposed. It allowed assessing the temporal changes of water distribution, its mobility and interaction with matrices in identified layers. |
Databáze: | OpenAIRE |
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