Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets

Autor: Władysław P. Węglarz, Piotr Kulinowski, Ewelina Juszczyk, Ewelina Baran, Przemysław Dorożyński, Josep M. Suñé-Negre, Artur Birczyński, Dorota Majda, Pilar Pérez-Lozano, Encarna García-Montoya
Rok vydání: 2021
Předmět:
magnetic resonance imaging (MRI)
differential scanning calorimetry (DSC)
Analytical chemistry
02 engineering and technology
030226 pharmacology & pharmacy
lcsh:Technology
Article
sodium alginate
Síntesi de fàrmacs
03 medical and health sciences
Matrix (mathematics)
Drug synthesis
0302 clinical medicine
multi-echo spin-echo (MSME) T2 relaxation time mapping
General Materials Science
lcsh:Microscopy
Water content
Sodium alginate
lcsh:QC120-168.85
hydrophilic polymeric matrices
chemistry.chemical_classification
Water transport
lcsh:QH201-278.5
Nanopartícules
compressed matrix tablets
lcsh:T
Spatiotemporal Analysis
Nondestructive analysis
mass transport
spatial water distribution
Polymer
021001 nanoscience & nanotechnology
ultrashort echo time (UTE)
Infiltration (hydrology)
chemistry
lcsh:TA1-2040
Nanoparticles
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
water–polymer interaction
0210 nano-technology
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Zdroj: Materials
Dipòsit Digital de la UB
Universidad de Barcelona
Materials, Vol 14, Iss 646, p 646 (2021)
Volume 14
Issue 3
ISSN: 1996-1944
Popis: Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. In the regions of high water content, where sampling was infeasible due to gel/sol consistency, magnetic resonance imaging (MRI) enabled characterization with an order of magnitude higher spatial resolution. The minimally hydrated layer (MHL), infiltration layer (IL) and fully hydrated layer (FHL) were identified in the unilaterally hydrated matrices. The MHL gained water from the first hour of incubation (5–10% w/w) and at 4 h total water content was 29–39% with nonfreezing pool of 28–29%. The water content in the IL was 45–47% and at 4 h it reached ~50% with the nonfreezing pool of 28% and T2 relaxation time <
10 ms. The FHL consisted of gel and sol layer with water content of 85–86% with a nonfreezing pool of 11% at 4 h and T2 in the range 20–200 ms. Hybrid destructive/nondestructive analysis of alginate matrices under hydration was proposed. It allowed assessing the temporal changes of water distribution, its mobility and interaction with matrices in identified layers.
Databáze: OpenAIRE
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