Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT)
| Autor: | Silvia Nozza, Cristina Mussini, Giampiero Carosi, Antonio Cascio, Francesco Mazzotta, Nicola Petrosillo, Marco Falcone, Roberto Parrella, Paolo Grossi, Antonio Chirianni, Carmelo Iacobello, Evangelista Sagnelli, Claudio Maria Mastroianni, Massimo Galli, Marco Tinelli, Marianna Meschiari, Marcello Tavio, Massimo Andreoni, Giovanni Di Perri, V. Portelli, Chiara Iaria, Orlando Armignacco, Caterina Sagnelli |
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| Přispěvatelé: | Mussini, C., Falcone, M., Nozza, S., Sagnelli, C., Parrella, R., Meschiari, M., Petrosillo, N., Mastroianni, C., Cascio, A., Iaria, C., Galli, M., Chirianni, A., Sagnelli, E., Iacobello, C., Di Perri, G., Mazzotta, F., Carosi, G., Tinelli, M., Grossi, P., Armignacco, O., Portelli, V., Andreoni, M., Tavio, M., Mussini C., Falcone M., Nozza S., Sagnelli C., Parrella R., Meschiari M., Petrosillo N., Mastroianni C., Cascio A., Iaria C., Galli M., Chirianni A., Sagnelli E., Iacobello C., Di Perri G., Mazzotta F., Carosi G., Tinelli M., Grossi P., Armignacco O., Portelli V., Andreoni M., Tavio M. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Coronavirus disease 2019 (COVID-19) 030106 microbiology Coronaviru practice guidelines as topic coronavirus randomized controlled trials as topic Guidelines medicine.disease_cause medical law.invention 03 medical and health sciences 0302 clinical medicine societies Randomized controlled trial law Pandemic italy medicine pneumonia 030212 general & internal medicine Intensive care medicine humans Societies Medical Coronavirus therapy SARS-CoV-2 business.industry COVID-19 Pneumonia Therapy Standard treatment General Medicine covid-19 sars-cov-2 societies medical standard of care COVID-19 Drug Treatment Clinical trial Infectious Diseases Position paper Observational study business Human |
| Zdroj: | Clinical Microbiology and Infection |
| Popis: | Scope Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic, reaching almost one million death worldwide. At present standard treatment for coronavirus disease 2019 (COVID-19) is not well defined because the evidence, either from randomized or observational studies, with conflicting results, has led to rapid changes in treatment guidelines. Our aim was to narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and interpretation of the data by experts who are treating patients in the frontline setting. Methods The panel conducted a detailed review of the literature and eventual press releases from randomized clinical trials for each possible available treatment. Inductive PubMed search waws performed for publications relevant to the topic, including all clinical trials conducted. The result was a flowchart with treatment indications for patients with COVID-19. Implications After 6 months of a pandemic situation and before a possible second coronavirus wave descends on Europe, it is important to evaluate which drugs proved to be effective while also considering that results from many randomized clinical trials are still awaited. Indeed, among treatments for COVID-19, only glucocorticoids have resulted in an association with a significant decrease in mortality in published randomized controlled trials. New therapeutic strategies are urgently needed. |
| Databáze: | OpenAIRE |
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