Hepatic cystic metastatic tumors from a locally controlled nasopharyngeal carcinoma
Autor: | Hsuan-Wei Chen, Wen-Chiuan Tsai, Tsai-Yuan Hsieh, Tzu-Ming Ou, Kai-Wen Chen |
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Rok vydání: | 2016 |
Předmět: |
Pathology
medicine.medical_specialty Liver tumor Ovary Cystic metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine Medicine General & Internal Biopsy medicine Hepatic cystic neoplasm Epstein–Barr virus early RNA medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine medicine.disease stomatognathic diseases medicine.anatomical_structure Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Immunohistochemistry 030211 gastroenterology & hepatology Pancreas business Nasopharyngeal |
Zdroj: | Scipedia Open Access Scipedia SL |
ISSN: | 2351-9797 |
DOI: | 10.1016/j.aidm.2014.09.001 |
Popis: | Liver cystic neoplasms are uncommon and vary from benign to overtly malignant. Liver cystic metastases are rare and mostly come from colon, pancreas, ovary, kidney, neuroendocrine, and prostate cancer. Nasopharyngeal carcinoma (NPC) with liver cystic metastasis has only been reported once. Here, we report a 52-year-old man with liver cystic metastasis from locally cured NPC. The patient received concurrent chemoradiotherapy for NPC 4 years ago and presented with a 6-month history of upper abdominal fullness and pain. No evidence of local recurrence of NPC was found at his regular follow-up examinations after concurrent chemoradiotherapy. Abdominal magnetic resonance imaging showed a large, well-defined, lobulated cystic lesion with poor contrast enhancement occupying both lobes of the liver. Hepatic cystic metastasis was suspected. Ultrasound-guided liver tumor biopsy was performed. Histological examinations disclosed a pattern of poorly differentiated squamous cell carcinoma with focal sarcomatoid differentiation based on the P40 immunohistochemical stain. In situhybridization for Epstein–Barr virus early RNAs confirmed the diagnosis of metastatic NPC. It is difficult to make a diagnosis in liver cystic neoplasms, especially from a rarely reported origin. In our case, we used clinical history and Epstein–Barr virus early RNAs as a specific marker to make an accurate diagnosis. |
Databáze: | OpenAIRE |
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