Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study
| Autor: | Ronald M. Schrader, Delia M. Vazquez, Anjel Vahratian, Lucy J. Allbaugh, Julie L. Chilimigras, Chelsea M. Clinton, Ellen Mozurkewich, Vivian Romero, Sheila M. Marcus, Susan E. Hamilton, Jennifer Anne Williams |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Generalized anxiety disorder Depression Postpartum 03 medical and health sciences 0302 clinical medicine Double-Blind Method Pregnancy Risk Factors Fatty Acids Omega-3 Obstetrics and Gynaecology History of depression Vitamin D and neurology medicine Humans 030212 general & internal medicine Vitamin D Mini-international neuropsychiatric interview 2. Zero hunger Psychiatric Status Rating Scales business.industry Obstetrics Depression Postpartum Period Beck Depression Inventory Obstetrics and Gynecology medicine.disease 3. Good health Pregnancy Complications Dietary Supplements Major depressive disorder Regression Analysis Female Pregnancy Trimesters business 030217 neurology & neurosurgery Postpartum period Maternal Serum Screening Tests Research Article |
| Zdroj: | BMC Pregnancy and Childbirth |
| ISSN: | 1471-2393 |
| DOI: | 10.1186/s12884-016-0988-7 |
| Popis: | Background Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy. Methods This study was a secondary analysis of a randomized trial designed to assess whether prenatal omega-3 fatty acid supplementation would prevent depressive symptoms. Pregnant women from Michigan who were at risk for depression based on Edinburgh Postnatal Depression Scale Score or history of depression were enrolled. Participants completed the Beck Depression Inventory (BDI) and Mini International Neuropsychiatric Interview at 12–20 weeks, 26–28 weeks, 34–36 weeks, and 6–8 weeks postpartum. Vitamin D levels were measured at 12–20 weeks (N = 117) and 34–36 weeks (N = 112). Complete datasets were available on 105 subjects. Using regression analyses, we evaluated the relationship between vitamin D levels with BDI scores as well as with MINI diagnoses of major depressive disorder and generalized anxiety disorder. Our primary outcome measure was the association of maternal vitamin D levels with BDI scores during early and late pregnancy and postpartum. Results We found that vitamin D levels at 12–20 weeks were inversely associated with BDI scores both at 12—20 and at 34–36 weeks’ gestation (P |
| Databáze: | OpenAIRE |
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