Hybrid Materials Based on Magnetic Iron Oxides with Benzothiazole Derivatives: A Plausible Potential Spectroscopy Probe
| Autor: | Teodorico C. Ramalho, Gustavo A Andolpho, Isael Aparecido Rosa, Francisco G.E. Nogueira, Eugenie Nepovimova, Lívia C. T. Lacerda, Elaine F. F. da Cunha, Silviana Corrêa, Kamil Kuca, Letícia C. Assis, Maíra dos Santos Pires |
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| Rok vydání: | 2021 |
| Předmět: |
Iron
Population Contrast Media Context (language use) engineering.material 010402 general chemistry 01 natural sciences DFT Ferric Compounds Catalysis Article Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound spectroscopy probe Rare Diseases Phase (matter) Humans Benzothiazoles Physical and Theoretical Chemistry Spectroscopy education Molecular Biology lcsh:QH301-705.5 chemistry.chemical_classification Ions education.field_of_study 010405 organic chemistry Chemistry Magnetic Phenomena Spectrum Analysis Organic Chemistry hybrid material General Medicine molecular docking Electron acceptor Feroxyhyte Combinatorial chemistry 0104 chemical sciences Computer Science Applications Benzothiazole lcsh:Biology (General) lcsh:QD1-999 engineering Hybrid material feroxyhyte |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 3980, p 3980 (2021) International Journal of Molecular Sciences Volume 22 Issue 8 |
| ISSN: | 1422-0067 |
| Popis: | Rare diseases affect a small part of the population, and the most affected are children. Because of the low availability of patients for testing, the pharmaceutical industry cannot develop drugs for the diagnosis of many of these orphan diseases. In this sense, the use of benzothiazole compounds that are highly selective and can act as spectroscopy probes, especially the compound 2-(4′-aminophenyl)benzothiazole (ABT), has been highlighted. This article reports the design of potential contrast agents based on ABT and iron to develop a new material with an efficient mechanism to raise the relaxation rate, facilitating diagnosis. The ABT/δ-FeOOH hybrid material was prepared by grafting (N-(4’-aminophenyl) benzothiazole-2-bromoacetamide) on the surface of the iron oxyhydroxide particles. FTIR spectra confirmed the material formations of the hybrid material ABT/δ-FeOOH. SEM analysis checked the covering of nanoflakes’ surfaces in relation to the morphology of the samples. The theoretical calculations test a better binding mode of compound with iron oxyhydroxide. Theoretical findings show the radical capture mechanism in the stabilization of this new material. In this context, Fe3+ ions are an electron acceptor from the organic phase. |
| Databáze: | OpenAIRE |
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