Malaria DNA vaccines in Aotus monkeys
| Autor: | Michal Margalith, Peter Hobart, Nicanor Obaldia, Martha Sedegah, Stephen L. Hoffman, Ruobing Wang, Yupin Charoenvit, RN Rossan, Denise L. Doolan, Dorina C. Maris, Robert A. Gramzinski |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_treatment
Plasmodium falciparum Protozoan Proteins Antibodies Protozoan Antigens Protozoan Enzyme-Linked Immunosorbent Assay Injections Intramuscular DNA vaccination Antigen Malaria Vaccines parasitic diseases Vaccines DNA Aotus trivirgatus medicine Animals Malaria Falciparum General Veterinary General Immunology and Microbiology biology Immunogenicity fungi Public Health Environmental and Occupational Health DNA Protozoan biology.organism_classification Virology Infectious Diseases Immunization Immunology Molecular Medicine Adjuvant Plasmodium yoelii |
| Zdroj: | Vaccine. 15:913-915 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(96)00270-8 |
| Popis: | In preparation for the development of DNA vaccines designed to produce protective antibodies against Plasmodium falciparum antigens (Ag), we conducted studies to optimize antibody responses in Aotus monkeys after immunization with the P. yoelli circumsporozoite (CSP) DNA vaccine. We demonstrate in Aotus monkeys that an intradermal route of immunization with a PyCSP plasmid DNA vaccine generates antibody responses equivalent to a multiple antigen peptide/adjuvant based vaccine, and that these data support the use of the intradermal route for initial studies of the efficacy of DNA vaccines in inducing protective antibodies against P. falciparum antigens in Aotus monkeys. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect