Influence of mechanical cell salvage on red blood cell aggregation, deformability, and 2,3-diphosphoglycerate in patients undergoing cardiac surgery with cardiopulmonary bypass
| Autor: | Willem van Oeveren, J. Ans M. Hagenaars, Y. John Gu, Wytze J. Vermeijden, Adrianus J. de Vries, Reindert Graaff |
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| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
AUTOTRANSFUSION Erythrocyte Aggregation Male medicine.medical_specialty Blood Loss Surgical DEVICE Preoperative care Erythrocyte aggregation law.invention AGGREGABILITY ACTIVATION TRANSFUSION law HEMODILUTION Erythrocyte Deformability Preoperative Care medicine Cardiopulmonary bypass Erythrocyte deformability Humans Cardiac Surgical Procedures ELDERLY-PATIENTS Aged 2 3-Diphosphoglycerate Cardiopulmonary Bypass business.industry Plateletpheresis RANDOMIZED CONTROLLED-TRIAL Cardiac surgery CENTRIFUGATION Red blood cell medicine.anatomical_structure Anesthesia Circulatory system Surgery Female Cardiology and Cardiovascular Medicine business Erythrocyte Transfusion Autotransfusion STORAGE |
| Zdroj: | Annals of thoracic surgery, 86(5), 1570-1575. ELSEVIER SCIENCE INC |
| ISSN: | 1552-6259 0003-4975 |
| Popis: | Background. Mechanical cell salvage is increasingly used during cardiac surgery. Although this procedure is considered safe, it is unknown whether it affects the red blood cell (RBC) function, especially the RBC aggregation, deformability, and the contents of 2,3-diphosphoglycerate (2,3-DPG). This study examines the following: ( 1) whether the cell salvage procedure influences RBC function; and ( 2) whether retransfusion of the salvaged blood affects RBC function in patients.Methods. Forty patients undergoing cardiac surgery with cardiopulmonary bypass were randomly allocated to a cell saver group ( n = 20) or a control group ( n = 20). In the cell saver group, the blood aspirated from the wound area and the residual blood from the heart-lung machine were processed with a continuous-flow cell saver before retransfusion. In the control group this blood was retransfused without processing. The RBC aggregation and deformability were measured with a laser-assisted optical rotational cell analyzer and 2,3,-DPG by conventional laboratory test.Results. The cell saver procedure did not influence the RBC aggregation but significantly reduced the RBC deformability ( p = 0.007) and the content of RBC 2,3-DPG ( p = 0.032). However, in patients receiving the processed blood, their intraoperative and postoperative RBC aggregation, deformability, and 2,3-DPG content did not differ from those of the control patients. Both groups of patients had a postoperative drop of RBC function as a result of hemodilution.Conclusions. The mechanical cell salvage procedure reduces the RBC deformability and the cell 2,3-DPG content. Retransfusion of the processed blood by cell saver does not further compromise the RBC function in patients undergoing cardiac surgery with cardiopulmonary bypass. |
| Databáze: | OpenAIRE |
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