Hypoglycemic and hypolipidemic effects of a polysaccharide from Fructus Corni in streptozotocin-induced diabetic rats
| Autor: | Wenchang Fan, Anchi Wei, Chenxi Li, Dongying Wang, Tao Yi, Yu-Xiang Ma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Drinking 02 engineering and technology Traditional Chinese medicine Pharmacology Polysaccharide medicine.disease_cause Biochemistry Antioxidants Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences Cornus Structural Biology Polysaccharides Diabetes mellitus medicine Animals Hypoglycemic Agents Insulin Secretion Molecular Biology 030304 developmental biology Cell Proliferation Hypolipidemic Agents chemistry.chemical_classification 0303 health sciences Cell growth Hydrolysis Muscles Body Weight General Medicine 021001 nanoscience & nanotechnology medicine.disease Streptozotocin Lipids Rats Oxidative Stress chemistry Liver Carbohydrate Metabolism 0210 nano-technology Oxidative stress Dyslipidemia Glycogen medicine.drug |
| Zdroj: | International journal of biological macromolecules. 133 |
| ISSN: | 1879-0003 |
| Popis: | Type-2 diabetes mellitus and its related complications including dyslipidemia and oxidative stress have been threating the health of a large number of patients all over the world. In this study, FCPC, one polysaccharide fraction separated from the polysaccharides of Chinese medicine Fructus Corni (FCPs), revealed obvious inhibitory effects against α-amylase and α-glucosidase, and marked insulin-sensitizing effect by increasing insulin secretion and promoting pancreatic β cell proliferation. In addition, in streptozotocin (STZ)-induced diabetic rats, the polysaccharide fraction not only significantly restrained the increase of food (p 0.05) and water (p 0.01) intake at 800 mg/kg, but also significantly controlled the increase of levels for sugar (p 0.01), insulin (p 0.05) and HOMA-IR value (p 0.05) in blood at 800 mg/kg on 42th day. Meanwhile, the reduced glycogen contents in liver (p 0.01) and skeletal (p 0.01) muscle caused by STZ were prominently improved, while the dyslipidemia status and oxidative damage were markedly ameliorated. Therefore, FCPC could be developed to natural medicines and functional foods in the treatment of diabetes and its complications including dyslipidemia status and oxidative stress. |
| Databáze: | OpenAIRE |
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