Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort:an Epi-IBD study
| Autor: | Vind, Ida, Thorsgaard, Niels, Salupere, Riina, Olsen, Jongero, Nielsen, Kari Rubek, Oksanen, Pia, Collin, Pekka, Katsanos, Konstantinnos H., Christodoulou, Dimitrios K., Skamnelos, Alexandros, Politis, Dimitrios, Ladefoged, Karin, Lakatos, Peter Laszlo, Végh, Zsuzsanna, Lakatos, Laszlo, Demenyi, Peterne, Kramli, Szabina Nemethne, O'Morain, Colm, Dal Piaz, Giualia, Santini, Alessia, Girardin, Giulia, d'Inca, Renata, Schwartz, Doron, Odes, Selwyn, Kupcinskas, Limas, Jonaitis, Laimas, Kiudelis, Gediminas, Valantiene, Irena, Grp, Epi-Ibd, Burisch, Johan, Kievit, Hendrika Adriana Linda, Andersen, Karina Winther, Andersen, Vibeke, Pedersen, Natalia, Kjeldsen, Jens, Valpiani, Daniela, Toca, Alina, Turcan, Svetlana, Katsanos, Konstantinos H., Fumery, Mathurin, Gower-Rousseau, Corinne, Zammit, Stefania Chetcuti, Ellul, Pierre, Eriksson, Carl, Halfvarson, Jonas, Magro, Fernando Jose, Duricova, Dana, Bortlik, Martin, Fernández, Alberto, Hernandez, Vicent, Myers, Sally, Sebastian, Shaji, Goldis, Adrian, Misra, Ravi, Arebi, Naila, Kaimakliotis, Ioannis P., Nikuina, Inna, Belousova, Elena, Brinar, Marko, Cukovic-Cavka, Silvija, Langholz, Ebbe, Munkholm, Pia, Niewiadomski, Ola, Bell, Sally, Turk, Niksa, Kaimakliotis, Ioannis, Nicolaou, Anastasia, Lukas, Milan, Shonova, Olga, Blichfeldt, Birgitte, Marker, Dorte, Carlsen, Katrine, Weimers, Petra, Aalykke, Clays, Dahlerup, Jens Frederik, Kudsk, Karen |
|---|---|
| Přispěvatelé: | Queen Ingrid's Hospital, Nuuk, Greenland, University of Edinburgh, Trinity College Dublin, Lithuanian University of Health Sciences [Kaunas, Lithuania], CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service Psychiatrie de l'Enfant et de l'Adolescent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Örebro University Hospital [Örebro, Sweden], IBD clinical and research centre, ISCARE, Prague, Czech Republic, Universidad Rey Juan Carlos [Madrid] (URJC), Hull and East Yorkshire Eye Hospital, Timisoara Hospital [Timisoara, Romania], Macquarie University, University of Copenhagen = Københavns Universitet (UCPH), Charles University [Prague] (CU), Gastro-Immuno Research Laboratory (GIRL), Dep. V, Hepatology and Gastroenterology, Aarhus University Hospital |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pediatrics AZATHIOPRINE crohn's disease [SDV]Life Sciences [q-bio] medicine.medical_treatment CLINICAL-COURSE Severity of Illness Index Inflammatory bowel disease CONVENTIONAL MANAGEMENT Cohort Studies 0302 clinical medicine Crohn Disease Neoplasms Epidemiology HISTORY Medicine Prospective Studies Prospective cohort study Colectomy education.field_of_study Crohn's disease Gastroenterology Middle Aged Prognosis Europe Hospitalization Cohort Disease Progression Female 030211 gastroenterology & hepatology epidemiology surgery for Ibd Cohort study Adult medicine.medical_specialty Population SURGERY RATES Young Adult 03 medical and health sciences Humans Immunologic Factors education Glucocorticoids METAANALYSIS business.industry medicine.disease EARLY COMBINED IMMUNOSUPPRESSION 030104 developmental biology HOSPITALIZATIONS business Intestinal Obstruction MEDICAL-MANAGEMENT Follow-Up Studies INFLAMMATORY-BOWEL-DISEASE |
| Zdroj: | Burisch, J, Kiudelis, G, Kupcinskas, L, Kievit, H A L, Andersen, K W, Andersen, V, Salupere, R, Pedersen, N, Kjeldsen, J & Epi-IBD Grp 2019, ' Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort : an Epi-IBD study ', Gut, vol. 68, no. 3, pp. 423-433 . https://doi.org/10.1136/gutjnl-2017-315568 Burisch, J, Kiudelis, G, Kupcinskas, L, Kievit, H A L, Andersen, K W, Andersen, V, Salupere, R, Pedersen, N, Kjeldsen, J, D'Incà, R, Valpiani, D, Schwartz, D, Odes, S, Olsen, J, Nielsen, K R, Vegh, Z, Lakatos, P L, Toca, A, Turcan, S, Katsanos, K H, Christodoulou, D K, Fumery, M, Gower-Rousseau, C, Zammit, S C, Ellul, P, Eriksson, C, Halfvarson, J, Magro, F J, Duricova, D, Bortlik, M, Fernandez, A, Hernández, V, Myers, S, Sebastian, S, Oksanen, P, Collin, P, Goldis, A, Misra, R, Arebi, N, Kaimakliotis, I P, Nikuina, I, Belousova, E, Brinar, M, Cukovic-Cavka, S, Langholz, E, Munkholm, P & Epi-IBD group 2019, ' Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort : an Epi-IBD study ', Gut, vol. 68, no. 3, pp. 423-433 . https://doi.org/10.1136/gutjnl-2017-315568 Gut Gut, 2019, 68 (3), pp.423-433. ⟨10.1136/gutjnl-2017-315568⟩ |
| ISSN: | 0017-5749 1468-3288 |
| DOI: | 10.1136/gutjnl-2017-315568 |
| Popis: | ObjectiveThe Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, PConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|