Further development of local IL-2 therapy of cancer: multiple versus single IL-2 treatment of transplanted murine colon carcinoma
| Autor: | Willem Den Otter, Halina Kusnierczyk, Krzysztof Krawczyk, Caspaar Bijleveld, Elżbieta Pajtasz-Piasecka, J. W. Koten |
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| Rok vydání: | 2004 |
| Předmět: |
Interleukin 2
Cancer Research Pathology medicine.medical_specialty Necrosis medicine.medical_treatment Immunology Nitric Oxide Mice Immune system Edema Tumor Cells Cultured medicine Carcinoma Animals Immunology and Allergy Macrophage colonic neoplasms / drug therapy Dose-Response Relationship Drug business.industry colonic neoplasms Cancer Neoplasms Experimental medicine.disease Mice Inbred C57BL Cytokine Oncology Mice Inbred DBA Colonic Neoplasms Interleukin-2 Female pathology medicine.symptom business neoplasms/therapy interleukin-2 / therapeutic use medicine.drug |
| Zdroj: | Cancer Immunology, Immunotherapy. 53:445-452 |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-003-0490-8 |
| Popis: | We have compared the effect of one and up to four local IL-2 treatments of transplanted MC38 colon carcinoma. A single IL-2 treatment prolonged the survival time ( p=0.015), but no cure was obtained. One local IL-2 treatment inhibited tumor growth for about 1 week. After the start of tumor regrowth, a further IL-2 injection was given. After four IL-2 injections 6 out of 13 mice were cured. Histological studies show that IL-2 induced a local vascular leakage syndrome leading to massive peritumoral edema and subsequent necrosis of tumor tissue. IL-2 also attracted infiltrating cells, mainly macrophages. Subsequent IL-2 injections led to complete tumor regression. We believe that the combination of necrotic tumor debris and the IL-2-induced macrophage reaction enhanced a tumor-specific immune response. This local IL-2 application was not toxic. |
| Databáze: | OpenAIRE |
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