The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases
| Autor: | George N. Chaldakov, Luigi Aloe, Gorana Rancic, Rouzha Z. Pancheva, Marcia Hiriart, Marco Fiore, Stanislav Yanev |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Basel: Springer Nature Switzerland, 2021 info:cnr-pdr/source/autori:Chaldakov GN, Aloe L, Rancic G, Pancheva RZ, Hiriart M, Fiore M, Yanev S./titolo:The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases./titolo_volume:/curatori_volume:/editore: /anno:2021 Cellular and Biochemical Mechanisms of Obesity ISBN: 9783030847623 |
| DOI: | 10.1007/978-3-030-84763-0_16 |
| Popis: | Currently, the most widespread global ailment is not COVID-19 or any 2 other such devastating infectious diseases. In fact, obesity has been recognized 3 as a prime risk in the development of cardiometabolic diseases (CMD), neurode- 4 generative diseases (NDD) and cancer and their morbidity and mortality signa- 5 ture. The pathobiology and therapy of obesity and related diseases are immensely 6 complex at the cellular and molecular levels. This scenario raises the question of 7 how such a complexity may be grappled in a more tangible manner. Since 2003, 8 we have been thinking "what nobody has yet thought about that which everybody 9 sees", namely, metabotrophic factors (MTF or metabotrophins, metabokines). They 10 include mainly (i) the neurotrophins nerve growth factor (NGF) and brain-derived 11 neurotrophic factor (BDNF), and (ii) the adipomyokines adiponectin, irisin, BDNF, 12 fibroblast growth factor-21 alike as adipose- and skeletal muscle-derived signaling |
| Databáze: | OpenAIRE |
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