The cholinergic locus: ChAT and VAChT genes
| Autor: | Jacques Mallet, Ricardo Cervini, Stephane Bejanin, Yoshio Oda, Fabrice Pajak, Leïla Houhou, Sylvie Berrard |
|---|---|
| Přispěvatelé: | Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie des processus adaptatifs (NPA) |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Transcription
Genetic Vesicular Acetylcholine Transport Proteins [SDV]Life Sciences [q-bio] Vesicular Transport Proteins Locus (genetics) Biology Choline O-Acetyltransferase 03 medical and health sciences 0302 clinical medicine Physiology (medical) Vesicular acetylcholine transporter Animals Promoter Regions Genetic Gene ComputingMilieux_MISCELLANEOUS 030304 developmental biology Genetics Regulation of gene expression 0303 health sciences General Neuroscience Intron Membrane Transport Proteins Promoter Choline acetyltransferase Acetylcholine Introns Rats Gene Expression Regulation Cholinergic [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Carrier Proteins 030217 neurology & neurosurgery |
| Zdroj: | Journal of Physiology-Paris Journal of Physiology-Paris, 1998, 92 (2), pp.145-147. ⟨10.1016/S0928-4257(98)80153-8⟩ |
| ISSN: | 0928-4257 |
| Popis: | The gene encoding the vesicular acetylcholine transporter has been localized within the first intron of the gene encoding choline acetyltransferase and is in the same transcriptional orientation. These two genes, whose products are required for the expression of the cholinergic phenotype, could therefore be coregulated. The promoters of both genes have been identified. The mechanisms that account for the regulation of the expression of both genes are now being investigated. |
| Databáze: | OpenAIRE |
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